Carla Bobbio, Thierry Rausis
2,4-Difluoro-, 2,4,6-trifluoro-, and 2,3,4,6-tetra(fluoro)pyridine undergo nucleophilic substitution preferentially if not exclusively at the 4-position. However, after the introduction of a trialkylsilyl group at C-3 or C-5, the halogen at the 6-(2-)posit ...
2005