Publications related to Acute liver failure

Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

Rolf Gruetter, Cristina Ramona Cudalbu, Dmitri Firsov, Hikari Ananda Infinity Yoshihara

Detoxification of ammonia by the urea cycle and maintenance of glucose homeostasis by gluconeogenesis are two critical functions of the liver. The bile duct ligation (BDL) model of cirrhosis was used to test the ability of hyperpolarized [6-13C]arginine an ...

2018

Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice

Hongxia Lei, Ana Francisca Leal Silva Soares

This study demonstrates the suitability of magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) for the imaging of congenital portosystemic shunts (PSS) in mice, a vascular abnormality in which mesenteric blood bypasses the liver and i ...

2018

MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

Cristina Ramona Cudalbu, Bernard Lanz, Veronika Rackayová

In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, a ...

Elsevier2017

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Kristina Schoonjans

beta-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb(-/-)mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we inv ...

Amer Soc Clinical Investigation Inc2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Jun Yong Kim, Dongryeol Ryu, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Karim Laurent Gariani, Pooja Jha

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Johan Auwerx, Dongryeol Ryu, Wei Wang, Karim Laurent Gariani, Zhou Zhou

Background & Aims: Mitochondria) dysfunction, oxidative stress, inflammation, and metabolic reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly(ADP-ribose) polymerases (PARP) and their interactions with sirtuins play ...

Elsevier Science Bv2017

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles

Frédéric Bruno Martin Gachon, Daniel Alain Dominique Marie Mauvoisin, Jingkui Wang

The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A major question is how the liver adapts to these diurnal changes in physiology. Here, we show that, ...

Cell Press2017

Raspberry Pi Driven Flow-Injection System for Electrochemical Continuous Monitoring Platforms

Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Federico Angiolini, Danilo Demarchi, Abuduwaili Tuoheti, Bruno Donato

Nowadays, there is an immense interest regarding new bio-sensing technologies, highlighting the need for effective validation of their capabilities. This necessity is more crucial when examining the proprieties of a sensor for continuous monitoring of a co ...

IEEE2017

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Cristina Ramona Cudalbu

Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairme ...

Springer Verlag2016

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Acute liver failure

Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice

MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles

A System for In Vivo Imaging of Hepatic Free Fatty Acid Uptake

Raspberry Pi Driven Flow-Injection System for Electrochemical Continuous Monitoring Platforms

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

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Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

A System for In Vivo Imaging of Hepatic Free Fatty Acid Uptake

MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles

Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice

Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Raspberry Pi Driven Flow-Injection System for Electrochemical Continuous Monitoring Platforms

Probing perturbed hepatic metabolism in bile-duct-ligated rats with hyperpolarized 13C pyruvate and arginine

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue