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Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

Cédric Xavier Paulou

Regenerative peripheral nerve interfaces are particularly invasive implant devices. They rely on the growth of axons from transected nerve stumps through electrode-bearing structures in order to establish highly efficient communication channels with the ne ...

EPFL2015

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin, Lin Jin

Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter ...

Elsevier2015

Evaluation of automatic neonatal brain segmentation algorithms: The NeoBrainS12 challenge

Elda Fischi Gomez, Laura Ioana Gui

A number of algorithms for brain segmentation in preterm born infants have been published, but a reliable comparison of their performance is lacking. The NeoBrainS12 study (http://neobrains12.isi.uu.nl), providing three different image sets of preterm born ...

Elsevier Science Bv2015

Accurate resistivity mouse brain mapping using microelectrode arrays

Philippe Renaud, Vincent Delattre, Patrick Fraering, Sébastien Mosser, Pierre Joris, Amélie Barbara Hildegarde Béduer

Electrical impedance spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an embedded micrometric electrode array. Combined with a peak resistance frequency method this allowed obtaining intrinsic resistivity valu ...

Elsevier2014

BOLD responses to trigeminal nerve stimulation

Rolf Gruetter, Carl Petersen, Nathalie Just

The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. ...

2010

Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery

Patrick Aebischer, Christopher Towne

BACKGROUND: Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic strategy for the treatment of persistent pain disorders such as neuropathic pa ...

2009

Fixing the location and dimensions of functional neocortical columns

Henry Markram

The quest to understand the way in which neurons interconnect to form circuits that function as a unit began when Ramon y Cajal concluded that axo-dendritic apposition were too conspicuous to be incidental and proposed that two neurons must be communicatin ...

2008

Role and mechanism of transient receptor potential (TRP) channels in gustatory and chemesthetic sensations associated with dietary molecules

Céline Riera

"Chemosensory perception", the perception of food chemicals, relies on the complex cooperation of gustatory, olfactory and somatosensory detection systems. In the oral cavity, the taste buds and the lingual branch of the trigeminal nerve are the organs tha ...

EPFL2008

Segmentation of Brain Structures in Presence of a Space-Occupying Lesion

Jean-Philippe Thiran, Meritxell Bach Cuadra, Olivier Cuisenaire

Brain deformations induced by space-occupying lesions may result in unpredictable position and shape of functionally important brain structures. The aim of this study is to propose a method for segmentation of brain structures by deformation of a segmented ...

2005

GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap

Patrick Aebischer, Eric Garrison Fine

The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15-mm-long gap in the rat sciatic nerve. Synthetic nerve guidance channels slowly releasing NGF and GDNF were fabricated and sutured to th ...

2002

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