Concept
Phosphatidylinositol
Related publications (34)
Membrane specificity of the human cholesterol transfer protein STARD4
Charlotte Julie Caroline Gehin
STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...
Academic Press Ltd- Elsevier Science Ltd2024S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel a ...
eLIFE SCIENCES PUBL LTD2021A Click Cage: Organelle‐Specific Uncaging of Lipid Messengers
Lipid messengers exert their function on short time scales at distinct subcellular locations, yet most experimental approaches for perturbing their levels trigger cell-wide concentration changes. Herein, we report on a coumarin-based photocaging group that ...
2018Interfacial Structure and Hydration of 3D Lipid Monolayers in Aqueous Solution
Sylvie Roke, Nikolay Smolentsev, Yixing Chen, Halil Ibrahim Okur, Evangelia Zdrali
Three-dimensional (3D) phospholipid monolayers at hydrophobic surfaces are ubiquitous and found in nature as adiposome organelles or in man-made materials such as drug delivery systems. However, the molecular level understanding of such monolayers remains ...
American Chemical Society2017