Concept
Retrograde signaling
Related publications (70)
Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics
Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon degeneration in Hereditary Spastic Paraplegia (HSP). We therefore asked how ...
New York2023Theoretical analysis of divalent cation effects on aptamer recognition of neurotransmitter targets
Nako Nakatsuka, Dmitry Momotenko, Annina Stuber
Aptamer-based sensing of small molecules such as dopamine and serotonin in the brain, requires characterization of the specific aptamer sequences in solutions mimicking the in vivo environment with physiological ionic concentrations. In particular, divalen ...
2023Extensive programmed centriole elimination unveiled in C. elegans embryos
Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...
AMER ASSOC ADVANCEMENT SCIENCE2023Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo
Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the dev ...
Berlin2023Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis
Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...
EPFL2022Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2 alpha HRI kinase
Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic neurotransmission and, through calcium signaling, generates nitric oxide (NO). Trying to unveil the ...
NATURE RESEARCH2021LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance
Maria del Carmen Sandi Perez, Olivia Zanoletti, Alexandre Claude Gustave Bacq, Roman Moreno Fernandez
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be invol ...
2020A Review of Microelectronic Systems and Circuit Techniques for Electrical Neural Recording Aimed at Closed-Loop Epilepsy Control
Alexandre Schmid, Reza Ranjandish
Closed-loop implantable electronics offer a new trend in therapeutic systems aimed at controlling some neurological diseases such as epilepsy. Seizures are detected and electrical stimulation applied to the brain or groups of nerves. To this aim, the signa ...
2020