Worthington is a city in and the county seat of Nobles County, Minnesota, United States. The population was 13,947 at the time of the 2020 census.
The city's site was first settled in the 1870s as Okabena Station on a line of the Chicago, St. Paul, Minneapolis and Omaha Railway, later the Chicago and North Western Railway (now part of the Union Pacific Railroad) where steam engines would take on water from adjacent Lake Okabena. More people entered, along with one A. P. Miller of Toledo, Ohio, under a firm called the National Colony Organization. Miller named the new city after his wife's maiden name.
The first European likely to have visited the Nobles County area of southwestern Minnesota was French explorer Joseph Nicollet. Nicollet mapped the area between the Mississippi and Missouri Rivers in the 1830s. He called the region "Sisseton Country" in honor of the Sisseton band of Dakota Indians then living there. It was a rolling sea of wide open prairie grass th