Concept
Selegiline
Related publications (36)
Investigating the Serotonergic Modulation of Orientation Tuning of Neurons in Primary Visual Cortex of Anesthetized Mice
Introduction: Sensory processing is profoundly regulated by brain neuromodulatory systems. One of the main neuromodulators is serotonin which influences higher cognitive functions, such as different aspects of perceptual processing. Accordingly, malfunctio ...
Tehran2023A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions
Vignayanandam Ravindernath Muddapu
In order to understand the link between substantia nigra pars compacta (SNc) cell loss and Parkinson's disease (PD) symptoms, we developed a multiscale computational model that can replicate the symptoms at the behavioural level by incorporating the key ce ...
FRONTIERS MEDIA SA2022REM sleep and muscle atonia in brainstem stroke: A quantitative polysomnographic and lesion analysis study
Important brainstem regions are involved in the regulation of rapid eye movement sleep. We hypothesized that brainstem stroke is associated with dysregulated rapid eye movement sleep and related muscle activity. We compared quantitative/qualitative polysom ...
WILEY2022Combining robotics with enhanced serotonin-driven cortical plasticity improves post-stroke motor recovery
Silvestro Micera, Stefano Lai, Maria Pasquini, Sara Conti, Marco Mainardi
Despite recent progresses in robotic rehabilitation technologies, their efficacy for post-stroke motor recovery is still limited. Such limitations might stem from the insufficient enhancement of plasticity mechanisms, crucial for functional recovery. Here, ...
PERGAMON-ELSEVIER SCIENCE LTD2021Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease
To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator) were ...
PERGAMON-ELSEVIER SCIENCE LTD2020Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice
Background Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell ...
2020Estimating The Degree of Sleepiness by Integrating Articulatory Feature Knowledge In Raw Waveform Based CNNs
Julian David Fritsch, Subrahmanya Pavankumar Dubagunta
Speech-based degree of sleepiness estimation is an emerging research problem. In the literature, this problem has been mainly addressed through modeling of low level of descriptors. This paper investigates an end-to-end approach, where given raw waveform a ...
Idiap2019Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression
Grégoire Courtine, Laetitia Danielle Philippine Baud, Isabel Laura Vollenweider
Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...
Biomed Central Ltd2015Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
Patrick Aebischer, Bernard Schneider, Sylvain Eric Lengacher, Julien Dusonchet
Mitochondrial dysfunction and oxidative stress have been implicated in the etiology of Parkinsons disease. Therefore, pathways controlling mitochondrial activity rapidly emerge as potential therapeutic targets. Here, we explore the neuronal response to pro ...
Oxford University Press2012Controlling specific locomotor behaviors through multidimensional monoaminergic modulation of spinal circuitries
Grégoire Courtine, Pavel Musienko, Rubia van den Brand
Descending monoaminergic inputs markedly influence spinal locomotor circuits, but the functional relationships between specific receptors and the control of walking behavior remain poorly understood. To identify these interactions, we manipulated serotoner ...
2011