Concept

Selegiline

Related publications (36)

Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF

Huntington's disease (HD) is an autosomal dominant genetic disease with devastating clinical effects on cognitive, psychological, and motor functions. These clinical symptoms primarily relate to the progressive loss of medium-spiny GABA-ergic neurons of th ...

2000

Gene transfer techniques for the delivery of GDNF in Parkinson's disease

Patrick Aebischer

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor disturbances caused by an alteration of the dopaminergic nigrostriatal system. Current symptomatic treatments for PD include dopaminergic drug administration, deep brain stimul ...

2000

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

Patrick Aebischer, Jean-Charles Bensadoun

Normal cellular metabolism produces oxidants which are neutralized within cells by antioxidant enzymes and other antioxidants. An imbalance between oxidants and antioxidants has been postulated to lead to the degeneration of specific populations of neurons ...

1998

Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis

Ursula Röthlisberger

The structural features of the active site of human monoamine oxidase B (MAO-B) were investigated by affinity labeling and site-directed mutagenesis. The pseudosubstrate inhibitor N-[2-aminoethyl]-5-chloro-2-pyridine carboxamide HCl (lazabemide) can be irr ...

1996

Transesterification of phenylalanine by means of chymotrypsin in the presence of dimethylsulfoxide

Albert Renken

The addn. of a miscible org. solvent, which decreases the water concn. of the system, is considered as a means to reduce hydrolysis when transesterification is the desired reaction. This approach is illustrated by the study of a model reaction, the kinetic ...

1992

Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices

Pierre Magistretti

The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensit ...

1983

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