Concept

Genotype

Related publications (83)

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Jacques Fellay, Istvan Bartha, Nimisha Chaturvedi, David Smith

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 5 ...

Nature Publishing Group2017

Kinetic considerations of two Sulfurospirillum spp. competing for tetrachloroethene

Christof Holliger, Julien Maillard, Géraldine Florence Buttet, Alexandra Marie Murray, Mélissa Burion

1 Laboratory for Environmental Biotechnology, ENAC-IIE-LBE, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland 2 DTU Environment, Department of Environmental Engineering, Technical University of Denmark, Lyngby, Denmark A well-establish ...

2017

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia

In a typical high-throughput drug screening (HTS) process, up to millions of chemical compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit a robust dose-response, as evidenced for example by a fluorescence signal. I ...

Royal Soc Chemistry2017

Familial segregation of group B streptococcal infection in a consanguineous kindred

Jacques Fellay, Alessandro Borghesi

Two cases of neonatal group B streptococcal (GBS) infection occurring in a large consanguineous kindred are described. The observation suggests that susceptibility to isolated GBS disease in this family may have been the result of an inborn error of immuni ...

Elsevier Sci Ltd2016

Alpha7 subunit of the nicotinergic acethylcholine receptor gene (CHRNA7) and perception of coherent motion in aging

Michael Herzog

Genetic variations of the alpha7 subunit of the nicotinergic acetylcholine receptor gene (CHRNA7) are linked to cognitive deficits in aging and schizophrenia. However, little is known about associations of the CHRNA7 gene with aged-related decline in visua ...

2016

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

Christoph Merten

Droplet-based microfluidics enables assays to be carried out at very high throughput (up to thousands of samples per second) and enables researchers to work with very limited material, such as primary cells, patient's biopsies or expensive reagents. An add ...

2016

De-anonymizing Genomic Databases Using Phenotypic Traits

Jean-Pierre Hubaux, Mathias Jacques Jean-Marc Humbert, Joachim Ludovic Hugonot, Kévin Clément Huguenin, Erman Ayday

People increasingly have their genomes sequenced and some of them share their genomic data online. They do so for various purposes, including to find relatives and to help advance genomic research. An individual's genome carries very sensitive, private inf ...

2015

Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments

Pierre Magistretti, Aurélie Delacrétaz

Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyce ...

Lippincott, Williams & Wilkins2015

The impact of host genetic variation on infection with HIV-1

The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibili ...

Nature Publishing Group2015

Transcriptomic characterization of the enzymatic antioxidants FeSOD, MnSOD, APX and KatG in the dinoflagellate genus Symbiodinium

Thomas Krüger

Background The diversity of the symbiotic dinoflagellate Symbiodinium sp., as assessed by genetic markers, is well established. To what extent this diversity is reflected on the amino acid level of functional genes such as enzymatic antioxidants that play ...

BioMed Central2015

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