Concept

Nicotinic agonist

Related publications (44)

Membrane-spanning bent helix modeling receptor protein channel function

Dansyl-(Ala-Aib-Ala-Aib-Ala)3-Pro-Ala-Aib-Ala-Aib-Ala-Trp-OMe [(I), where Aib is a-aminoisobutryate] is a bent a-helical peptide which displays ion channel activity characteristic of the nicotinic acetylcholine receptor. The membrane organization, side-cha ...

1990

Long-lasting facilitation of excitatory postsynaptic potentials in the rat hippocampus by acetylcholine

Henry Markram

The effects of acetylcholine (ACh) on excitatory postsynaptic potentials (EPSPs) evoked by stimulating Schaffer-commissural afferents and on ionophoretically applied L-glutamate ligands, were investigated in CA1 neurones of hippocampal slices using curr ...

1990

Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus

Henry Markram

The effect of acetylcholine (ACh) on intracellular responses to ionophoretic application of N-methyl-D-aspartate (NMDA) was examined in rat hippocampal slice. Recordings were obtained from CA1 neurons under current- and voltage-clamp conditions. Drugs were ...

1990

Synthetic helical polypeptide models the acetylcholine receptor channel function

Horst Vogel

A review with 11 refs. on a fluorescent Aib-contg. peptide model for the acetylcholine receptor ion channel. This peptide induces single-channel conductance in planar lipid bilayers exhibiting one single open conductance state and weakly voltage-dependent ...

1989

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