East Palestine (ˌpæləˈstiːn ) is a village in northeastern Columbiana County, Ohio, United States. The population was 4,761 at the 2020 census. Located on the state's border with Pennsylvania, East Palestine is about south of Youngstown and northwest of Pittsburgh. It is part of the Salem micropolitan area.
The city was home to industries in ceramics and tire manufacturing from the 1870s until the mid-1960s. East Palestine is located along the Norfolk Southern Railway and has a freight train station. On February 3, 2023, the village was near the site of a major derailment that spilled vinyl chloride and triggered significant evacuations in the jurisdiction.
East Palestine was platted in 1828 by Thomas McCalla and William Grate, initially known as Mechanicsburg. In 1833, it was renamed after the Middle Eastern region of Palestine. The name was changed as part of a religious nomenclature in the area, including communities such as Enon Valley, Medin