Defiance is a city in and the county seat of Defiance County, Ohio, United States, about southwest of Toledo and northeast of Fort Wayne, Indiana, in Ohio's northwestern corner. The population was 17,066 at the 2020 census.
The city contains the site of Fort Defiance, built by General "Mad" Anthony Wayne in August 1794, during the Northwest Indian War at the confluence of the Auglaize and Maumee rivers. General Wayne surveyed the land and declared to General Scott, "I defy the English, Indians, and all the devils of hell to take it." Using the fort as a base of operations, Wayne ordered his troops to destroy Native American crops and villages within a radius of around the fort. Today a pair of cannons outside the city library on the Maumee River overlook the confluence and mark the location of Fort Defiance, along with a mounded outline of the fort walls. The city was named after Fort Defiance.
From Fort Defiance, the U.S. forces moved northeast along the Maumee