Publications related to Non-homologous end joining

Opposing chromatin remodelers control transcription initiation frequency and start site selection

Precise nucleosome organization at eukaryotic promoters is thought to be generated by multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an integrated analysis of chromatin remodeler binding and nucleosome occupancy fol ...

NATURE PUBLISHING GROUP2019

Mechanism suppressing charge recombination at iodine defects in CH3NH3PbI3 by polaron formation

Alfredo Pasquarello, Francesco Ambrosio, Julia Anna Wiktor

Metal-halide perovskites exhibit high efficiencies in photovoltaic applications and low recombination rates, despite the high concentrations of intrinsic defects. We here study the hole trapping at the negative iodine interstitial, which corresponds to the ...

2018

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

Christian Iseli, Nicolas Mermod, Thomas Junier, Samuel Neuenschwander, Ioannis Xenarios

Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non-homologous end-joining (NHEJ) or homologous r ...

2017

The telomeric DNA damage response occurs in the absence of chromatin decompaction

Joachim Lingner, Suliana Manley, Kyle Michael Douglass, Verena Pfeiffer, Aleksandra Vancevska

Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this function has been attributed to its abilities to trigge ...

Cold Spring Harbor Laboratory2017

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Eric Aeby, Jing Ye, Bei Pei

The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps similar to 90 bp of DNA through several lysine and arginine residues localiz ...

Cell Press2016

Recombinant protein production from stable mammalian cell lines and pools

David Hacker, Sowmya Balasubramanian

We highlight recent developments for the production of recombinant proteins from suspension-adapted mammalian cell lines. We discuss the generation of stable cell lines using transposons and lentivirus vectors (non-targeted transgene integration) and site- ...

Elsevier2016

ALT Telomeres Get Together with Nuclear Receptors

Joachim Lingner, Eric Aeby

Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only tri ...

Cell Press2015

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Homing endonucleases are useful tools for genome modification because of their capability to recognize and cleave specifically large DNA targets. These endonucleases generate a DNA double strand break that can be repaired by the DNA damage response machine ...

American Society for Biochemistry and Molecular Biology2015

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Non-homologous end joining

Opposing chromatin remodelers control transcription initiation frequency and start site selection

The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors

Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection

Mechanism suppressing charge recombination at iodine defects in CH3NH3PbI3 by polaron formation

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

The telomeric DNA damage response occurs in the absence of chromatin decompaction

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Recombinant protein production from stable mammalian cell lines and pools

ALT Telomeres Get Together with Nuclear Receptors

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

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TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Opposing chromatin remodelers control transcription initiation frequency and start site selection

Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Mechanism suppressing charge recombination at iodine defects in CH3NH3PbI3 by polaron formation

MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering

The telomeric DNA damage response occurs in the absence of chromatin decompaction

Recombinant protein production from stable mammalian cell lines and pools

ALT Telomeres Get Together with Nuclear Receptors

The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors