The last universal common ancestor (LUCA) is the most recent population from which all organisms now living on Earth share common descent—the most recent common ancestor of all current life on Earth. This includes all cellular organisms, but not necessarily viruses. The LUCA is not the first life on Earth; it may have lived among a diversity of other organisms whose descendants all died out. Rather LUCA is the most recent form from which all surviving life on Earth is descended.
While no specific fossil evidence of the LUCA exists, the detailed biochemical similarity of all current life makes it plausible. Its characteristics can be inferred from shared features of modern genomes. These genes describe a complex life form with many co-adapted features, including transcription and translation mechanisms to convert information from DNA to mRNA to proteins. The LUCA probably lived in the high-temperature water of deep sea vents near ocean-floor magma flows around 4 billion years ago.
A phylogenetic tree directly portrays the idea of evolution by descent from a single ancestor. An early tree of life was sketched by Jean-Baptiste Lamarck in his Philosophie zoologique in 1809. Charles Darwin more famously proposed the theory of universal common descent through an evolutionary process in his book On the Origin of Species in 1859: "Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed." The last sentence of the book begins with a restatement of the hypothesis:
"There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one ..."
The term "last universal common ancestor" or "LUCA" was first used in the 1990s for such a primordial organism.
In 2016, Madeline C. Weiss and colleagues genetically analyzed 6.1 million protein-coding genes and 286,514 protein clusters from sequenced prokaryotic genomes representing many phylogenetic trees, and identified 355 protein clusters that were probably common to the LUCA.
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