Concept

Metabolic acidosis

Related publications (35)

Systematic Metabolic Engineering of Recombinant Xylose-Utilizing S. cerevisiae: Strategies for Improving Xylose Uptake Rate

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh

Recent advancements in metabolomics and fluxomics methods and ever-increasing amount of available experimental data necessitate systems-oriented methodologies for efficient and systematic integration of data into consistent large-scale kinetic models capab ...

2012

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

We evaluated the metabolic impact of farnesoid X receptor (FXR) activation by administering a synthetic FXR agonist (GW4064) to mice in which obesity was induced by a high fat diet. Administration of GW4064 accentuated body weight gain and glucose intolera ...

2011

Longitudinal MR Assessment of Hypoxic Ischemic Injury in the Immature Rat Brain

Rolf Gruetter, Yohan Van de Looij

Extremely preterm infants commonly show brain injury with long-term structural and functional consequences. Three-day-old (P3) rat pups share some similarities in terms of cerebral development with the very preterm infant (born at 24-28 weeks of gestation) ...

Wiley-Blackwell2011

Protein deacetylation by SIRT1: An emerging key post- translational modification in metabolic regulation

Johan Auwerx, Jiujiu Yu

The biological function of most proteins relies on reversible post-translational modifications, among which phosphorylation is most prominently studied and well recognized. Recently, a growing amount of evidence indicates that acetylation-deacetylation rea ...

Elsevier2010

Caloric restriction, SIRT1 and longevity

Johan Auwerx, Carlos Canto Alvarez

More than 70 years after its initial report, caloric restriction stands strong as the most consistent non- pharmacological intervention increasing lifespan and protecting against metabolic disease. Among the different mechanisms by which caloric restrictio ...

2009

The role of sirtuins in the control of metabolic homeostasis

Johan Auwerx, Jiujiu Yu

Recently the function of the sirtuin family, named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2), has received a lot of attention, as their beneficial impact on longevity was linked to their effects on meta ...

2009

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

Johan Auwerx

The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a Pro12Ala knockin model, that on chow diet, Ala/Ala mice are le ...

2009

pH control for enhanced reductive bioremediation of chlorinated solvent source zones

David Andrew Barry, Clare Robinson

Enhanced reductive dehalogenation is an attractive treatment technology for in situ remediation of chlorinated solvent DNAPL source areas. Reductive dehalogenation is an acid-forming process with hydrochloric acid and also organic acids from fermentation o ...

Elsevier2009

TGR5-mediated bile acid sensing controls glucose homeostasis

Johan Auwerx, Kristina Schoonjans, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez

TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- a ...

2009

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Johan Auwerx, Carlos Canto Alvarez

PURPOSE OF REVIEW: Peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1alpha) has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1alpha activity is not constant and can be finely tuned in r ...

2009

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