Publications related to Aging-associated diseases

On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong

Like other animals, C. elegans nematodes have the ability to socially interact and to communicate through exchange and sensing of small soluble signaling compounds that help them cope with complex environmental conditions. For the time being, worm biocommu ...

Royal Soc Chemistry2016

Silver nanoparticles inhibit fish gill cell proliferation in protein-free culture medium

Kristin Schirmer, Laura Sigg, Renata Behra, Yang Yue

While short-term exposures of vertebrate cells, such as from fish, can be performed in defined, serum-free media, long-term cultures generally require addition of growth factors and proteins, normally supplied with a serum supplement. However, proteins are ...

Taylor & Francis Ltd2016

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

ALS patient iPSC-derived motor neurons aim to model disease phenotypes. The authors demonstrate that these cells transcriptomically resemble fetal rather than adult spinal motor neurons, and familial and sporadic forms of ALS disrupt gene networks and path ...

2016

Aging of asymmetric dynamics on the random energy model

Jean-Christophe Mourrat

We show aging of Glauber-type dynamics on the random energy model, inthe sense that we obtain the annealed scaling limits of the clock process and of theage process. The latter encodes the Gibbs weight of the configuration occupied by thedynamics. Both lim ...

Springer2015

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite, Shreya Narasimhan

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Nature Publishing Group2015

The effects of aging on perception and cognition

Michael Herzog, Aaron Michael Clarke, Daniela Herzig

The developed world is aging faster than ever before. Even in the absence of neurodegenerative disease, aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually foun ...

Association for Research in Vision and Ophthalmology2015

Aging and perception

Michael Herzog, Aaron Michael Clarke

The developed world is aging faster than ever before. Even in the absence of neurodegenerative disease, aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually foun ...

Sage Publications Ltd2015

Towards the Identification of Disease Signatures

Anastasia Ailamaki, Thomas Heinis, Manolis Karpathiotakis

The identification of biological signatures of diseases will enable the development of new biologically grounded classifications of brain diseases, leading to a new systematic understanding of their causes, and new diagnostic tools. In this paper we presen ...

Springer International Publishing2015

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Patrick Aebischer, Bernard Schneider, Wojciech Janusz Bobela

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic effects ...

Mdpi Ag2015

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Grégoire Courtine, Laetitia Danielle Philippine Baud, Isabel Laura Vollenweider

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...

Biomed Central Ltd2015

Aging-associated diseases

On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites

Silver nanoparticles inhibit fish gill cell proliferation in protein-free culture medium

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Aging of asymmetric dynamics on the random energy model

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

The effects of aging on perception and cognition

Aging and perception

Towards the Identification of Disease Signatures

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

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On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites

Silver nanoparticles inhibit fish gill cell proliferation in protein-free culture medium

Aging of asymmetric dynamics on the random energy model

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

The effects of aging on perception and cognition

Aging and perception

Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

Towards the Identification of Disease Signatures

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression