Wattsville is an unincorporated community in Laurens County, South Carolina, United States. The town name is derived from Watts Mill, a textile mill in the center of town. The area is listed as the Wattsville census-designated place (CDP) for statistical purposes. The population of the CDP was 1,635 at the 2010 census. It is part of the Greenville–Mauldin–Easley Metropolitan Statistical Area.
Wattsville is located in central Laurens County at and is bordered to the southwest by the city of Laurens, the county seat. U.S. Route 221 passes through the center of Wattsville, leading north to Spartanburg and south through Laurens to Greenwood. South Carolina Highway 49 leaves US 221 in Wattsville, leading northeast to Union. Interstate 385 passes north of Wattsville, with access from both US-221 and SC-49.
According to the United States Census Bureau, the CDP has a total area of , all land. The center of the community occupies a ridge between south-flowi