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Related publications (54)
cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel
Bart Deplancke, Vincent Roland Julien Gardeux, Virginie Sandra Braman, Maroun Bou Sleiman, Riccardo Dainese, Maria Litovchenko, Michael Vincent Frochaux, Dani Osman, Brian Dennis Hollis, Tommaso Andreani
Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...
2020Comprehensive analysis of PM20D1 QTL in Alzheimer's disease
Johannes Gräff, Liliane Glauser, Jose Vicente Sanchez Mut
Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...
BMC2020A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma
Anthony Christopher Davison, Jörg Hager, Hélène Ruffieux, Radu Popescu
Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large multiplicity burden, which hampers the ...
PUBLIC LIBRARY SCIENCE2020Mutation update: TGFBI pathogenic and likely pathogenic variants in corneal dystrophies
Human transforming growth factor beta-induced (TGFBI), is a gene responsible for various corneal dystrophies. TGFBI produces a protein called TGFBI, which is involved in cell adhesion and serves as a recognition sequence for integrins. An alteration in cel ...
2019Sex-dependent and sex-independent regulatory systems of size variation in natural populations
Bart Deplancke, Vincent Roland Julien Gardeux, Ernst Hafen
Size of organs/organisms is a polygenic trait. Many of the growth-regulatory genes constitute conserved growth signaling pathways. However, how these multiple genes are orchestrated at the systems level to attain the natural variation in size including sex ...
WILEY2019Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster
Work on Drosophila melanogaster paved the way to our current understanding of modern genetics. Since then, this model organism has contributed greatly to various fields such as neurobiology, development, and immunology. The discovery and analysis of the va ...
EPFL2019Large-scale variational inference for Bayesian joint regression modelling of high-dimensional genetic data
Genetic association studies have become increasingly important in understanding the molecular bases of complex human traits. The specific analysis of intermediate molecular traits, via quantitative trait locus (QTL) studies, has recently received much atte ...
EPFL2019Relationships between key functional traits of the waterlily Nuphar lutea and wetland nutrient content
Little attention has been paid to how aquatic habitat characteristics affect the traits of plant species. Nuphar lutea (L.) Sm. is a keystone species distributed across temperate regions of Europe, northwest Africa and western Asia. Its apparently low phen ...
2019The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform
Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Hüseyin Baris Atakan
Fluctuations and deterioration in environmental conditions potentially have a phenotypic impact that extends over generations. Transgenerational epigenetics is the defined term for such intergenerational transient inheritance without an alteration in the D ...
2019Novel PDE6B Mutation Presenting with Retinitis Pigmentosa - A Case Series of Three Patients
Background Retinitis pigmentosa (RP) affects 2.5 million people worldwide. Increased identification of causative gene defects and the increasing possibility of treatment necessitates better knowledge of phenotype-genotype correlations to help identify pati ...
2019