Concept

Ligand-gated ion channel

Related publications (236)

Integrated microfluidic system for non-invasive electrophysiological measurements on Xenopus oocytes

We developed a new non-invasive integrated microsystem for electrophysiological measurements on Xenopus laevis oocytes. The Xenopus oocyte is a well-known expression system for various kinds of ion channels that are of potential interest for drug screening ...

EPFL2008

AMPA receptor imaging by infrared scanning near-field optical microscopy

Giorgio Margaritondo, Kai Johnsson, Harald Hirling, Johanna Generosi, Michel Kropf

Infrared scanning near-field optical microscopy is used to detect AMPA-type glutamate receptor clusters in hippocampal neuron cells. AMPA's GluR2-subunits were marked with the fluorophore Alexa488 and high-resolution micrographs were taken at 6.25 µm wavel ...

2008

Population response in autaptic and disynaptic inhibitory cortical microcircuitry: a computational study

Vincent Delattre

The dynamic of the neuronal response is highly influenced by the nature and the amount of noise that a neuron experienced, this noise being either external and internal to the neuron. The 10 000 synaptic afferents may not fire synchronously, hence, cause t ...

2008

Contact and edge effects in graphene devices

Klaus Kern, Marko Burghard, Kannan Balasubramanian, Ralf Thomas Weitz, Eduardo Jian Hua Lee

Electrical transport studies on graphene have been focused mainly on the linear dispersion region around the Fermi level(1,2) and, in particular, on the effects associated with the quasiparticles in graphene behaving as relativistic particles known as Dira ...

2008

Tuning the self-assembly of lanthanide triple stranded heterobimetallic helicates by ligand design

Rosario Scopelliti, Jean-Claude Bünzli, Thomas Binderup Jensen

The heterobitopic ligands LAB4 and LAB5 have been designed and synthesised with the ultimate aim of self-assembling dual-function lanthanide complexes containing either a magnetic and a luminescent probe or two luminescent probes emitting at different wave ...

2008

Cripto localizes nodal at the limiting membrane of early endosomes

Daniel Constam, Stéphane Baflast

Cripto is a glycosylphosphatidylinositol (GPI)-anchored co-receptor of Nodal and several other transforming growth factor-beta (TGF-beta) family ligands. It contains an epidermal growth factor (EGF)-like motif and a Cripto-FRL1-Cryptic (CFC) domain, which ...

2008

New conjugate of agonist ligand directed to ligand-gated ion channels of cysteine loop-family with chromophore, useful, e.g. in receptor proteins/their interaction with agonistic ligand and to study the effect of unlabelled ligands

Horst Vogel, Rudolf Hovius, Jörg Grandl

NOVELTY - Conjugate (I) of an agonist ligand directed to ligand-gated ion channels (LGICs) of the Cys loop-family with a chromophore, is new. USE - (I) is useful in the receptor proteins and/or their interaction with the agonistic ligand, where the interac ...

2007

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel

Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that switches upon activation from a closed state to a full conducting state. We found that the mutation delta S268K, located at 12' position of the second transmembrane domain of t ...

2007

Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function

Johan Auwerx, Kristina Schoonjans

Epidermal Langerhans cells (LC) play a pivotal role in initiating and maintaining primary immune responses in the skin. In the present study, we asked whether peroxisome proliferator-activated receptor-alpha (PPARalpha) activation modulates LC function. Ou ...

2007

The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MIoK1 at 16 angstrom resolution

Henning Paul-Julius Stahlberg

The gating ring of cyclic nucleotide-modulated channels is proposed to be either a two-fold symmetric dimer of dinners or a four-fold symmetric tetramer based on high-resolution structure data of soluble cyclic nucleotide-binding domains and functional dat ...

Elsevier BV2007

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