Concept

Half-life

Related publications (50)

Chemical macrocyclization of peptides fused to antibody Fc fragments

Christian Heinis, David Hacker, Laure Menin, Alessandro Angelini, Philippe Diderich, Julia Morales Sanfrutos, Sarah Thurnheer

To extend the plasma half-life of a bicyclic peptide antagonist, we chose to link it to the Fc fragment of the long-lived serum protein IgG1. Instead of chemically conjugating the entire bicyclic peptide, we recombinantly expressed its peptide moiety as a ...

Amer Chemical Soc2012

Template-free self-assembly of hierarchical ZnO structures from nanoscale building blocks

Klaus Kern, Kannan Balasubramanian, Vivek Pachauri

We study chemical bath deposition method for synthesizing large variety constructions of ZnO nanostructures. By varying reaction kinetics we control the shape, size and morphology to yield flower-like, rolling-pin-like, viscous-fingers-like and antenna-lik ...

2010

Strategies to prolong the plasma residence time of peptide drugs

Christian Heinis, Lisa Pollaro

Peptides are an attractive class of molecules for the development of therapeutics because they combine unique properties such as high binding affinity, excellent target specificity, low toxicity and a relatively small mass. However, the short in vivo half- ...

2010

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Davide Demurtas, Jeffrey Alan Hubbell, Simone Cavadini, Tyler Nerton Thacher, Yun Suk Jo, Jay Gantz

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

Atomic Layer Deposition of Hafnium Oxide from Tetrakis(ethylmethylamino)hafnium and Water Precursors

We have calculated the atomistic mechanism for the HfO2 atomic layer deposition (ALD) using Hf(NEtMe)(4) and H2O precursors using density functional theory. On hydroxylated Si surface, our results show overall Hf(NEtMe)(4) half-reaction is exothermic by 1. ...

American Chemical Society2007

Quantum chemical study of the initial surface reactions in atomic layer deposition of TiN on the SiO2 surface

Wei Chen, Min Xu

Cluster calculations employing hybrid density functional theory have been carried out to examine the initial surface reactions in atomic layer deposition (ALD) of TiN thin films on the SiO2 surface using TiCl4 and NH3 as precursors. The potential energy su ...

Institute of Physics2006

Sintering of NaCl powder: Mechanisms and first stage kinetics

Andreas Mortensen, Jean-François Despois

Isothermal NaCl sintering experiments are conducted between 500 and 790 degrees C on powders 75, 100, 150 and 400 mu m in average diameter. Along with literature data, the results are compared with theoretical predictions for the initial stage of sintering ...

2006

Quantum chemical study of the initial surface reactions of HfO2 atomic layer deposition on the hydroxylated GaAs(001)-4×2 surface

Wei Chen, Min Xu

Initial surface reaction mechanism for atomic layer deposition of HfO2 on the hydroxylated GaAs(001)-4x2 surface using HfCl4 and H2O as precursors is investigated using hybrid density functional theory. The reaction between HfCl4 and H2O with the hydroxyla ...

American Institute of Physics2006

Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1

Lukas Kühn, Barbara Grisoni-Neupert

Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability determinants can entirely be attributed to the 3' untranslated region. By grafting segments of this region to stable green fluorescent protein mRNA and subsequent scanning ...

2006

Spectrophotometric determination of ferrate (Fe(Vl)) in water by ABTS

Urs von Gunten

A new method for the determination of low concentrations (0.03-35 mu M) of the aqueous ferrate (Fe(VI)) was developed. The method is based on the reaction of Fe(VI) with 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) which forms a green radical ...

2005

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