Concept

Hyperkinesia

Related publications (32)

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

System Design and Advanced Circuit Techniques for Bi-Directional Brain-Machine Interfaces

Wen-Yang Hsu

Bi-directional brain-machine interfaces (BBMIs) that can capture electrophysiological signals and provide feedback through electrical stimulation are emerging tools with various applica-tions in fundamental neuroscience research as well as in clinical trea ...

EPFL2018

Assessing the clinical outcome of Vim radiosurgery with voxel-based morphometry: visual areas are linked with tremor arrest!

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Meritxell Bach Cuadra, Constantin Tuleasca, Elena Najdenovska

Radiosurgery (RS) is an alternative to open standard stereotactic procedures (deep-brain stimulation or radiofrequency thalamotomy) for drug-resistant essential tremor (ET), aiming at the same target (ventro-intermediate nucleus, Vim). We investigated the ...

Springer Verlag2017

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks

Michele Giugliano

Cell assemblies manipulation by optogenetics is pivotal to advance neuroscience and neuroengineering. In in vivo applications, photostimulation often broadly addresses a population of cells simultaneously, leading to feed-forward and to reverberating respo ...

Nature Publishing Group2016

Marinesco-Sjogren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS

Bernard Schneider, Céline Ruegsegger, Niran Maharjan

Mechanisms underlying motor neuron subtype selective endoplasmic reticulum (ER) stress and associated axonal pathology in amyotrophic lateral sclerosis (ALS) remain unclear. Here we show that the molecular environment of the ER between motor neuron subtype ...

Nature Publishing Group2015

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Rubia van den Brand, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Cell-type specific function of GABAergic neurons in layers 2 and 3 of mouse barrel cortex

Carl Petersen

GABAergic neurons are a minor fraction of the neocortical neuronal population, but they are highly diverse in their features. The GABAergic neurons can be divided into three largely non-overlapping groups, defined through the expression of ionotropic serot ...

Current Biology Ltd2014

Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity

Ozgün Gökce, Davide Franceschini

Here, we describe the selection and optimization of a chemical series active in both a full-length and a fragment-based Huntington's disease (HD) assay. Twenty-four thousand small molecules were screened in a phenotypic HD assay, identifying a series of co ...

Amer Chemical Soc2013

Effect of realistic modeling of deep brain stimulation on the prediction of volume of active tissue

Juan Ramon Mosig, Laleh Golestanirad

Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease, essential tremor and dystonia. It has also been successfully applied to treat various other neurological and psychiatric conditions including depression and obsessive-com ...

2012

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

Wiley-Blackwell2012

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