Concept

Immunosenescence

Related publications (43)

CD80 costimulation is required for Th2 cell cytokine production but not for antigen-specific accumulation and migration into the lung

The CD28 ligands CD80 and CD86 are expressed on APC, and both provide costimulatory function. However, the reason for the expression of two separate CD28 ligands remains unclear. We have previously shown that blockade of CD80 costimulation by Y100F-Ig, a C ...

2001

Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis.

Didier Trono

CD4, a member of the immunoglobulin superfamily, is not only expressed in T4 helper lymphocytes but also in myeloid cells. Receptor-mediated endocytosis plays a crucial role in the regulation of surface expression of adhesion molecules such as CD4. In T ly ...

1997

Memory TCR repertoires analyzed long-term reflect those selected during the primary response

Philipp Bucher, Anne Wilson

Normal T cell repertoire selection and evolution in antigen-specific responses is poorly understood. We have recently described an MHC class I-restricted response characterized by an overwhelming expansion of CD8 cells expressing a Vbeta10 TCR, thus allowi ...

1996

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