Concept

Drug liberalization

Related publications (92)

Modeling a zero-order drug release pattern with multi-laminated hydrogels

Diffusion-controlled hydrogel polymeric matrix devices have been among the most widely used drug delivery systems. How ever in homogeneous hydrogel the diffusional distance increase with time and hence, the release rate decreases. That results in high rele ...

2012

Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells

Paul Joseph Dyson, Michael Groessl

An approach to characterize the interactions of RAPTA-T, a novel ruthenium-based anticancer drug candidate with intriguing antimetastatic properties, with human ovarian cancer cells in vitro is described. The distribution profile of the metallodrug within ...

Royal Society of Chemistry2012

Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates

Li Tang

Drug-containing nanoparticles (NPs) with monodisperse, controlled particle sizes are highly desirable for drug delivery. Accumulating evidence suggests that NPs with sizes less than 50 nm demonstrate superior performance in vitro and in vivo. However, it i ...

American Chemical Society2012

Searching for the Protein Targets of Bioactive Molecules

Kai Johnsson, Christopher Chidley, Cindy Fellay, Hirohito Haruki, Miriam Grønlund Pedersen, Simone Moser

The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal phy ...

Schweizerische Chemische Gesellschaft2011

Detection of Farnesyltransferase Interface Hot Spots through Computational Alanine Scanning Mutagenesis

Marta Andreia Da Silva Perez

In this study, we present a detailed characterization of the full α/β interface in the farnesyltransferase (FTase) enzyme, an important target in drug design efforts. This characterization is presented in terms of hot spots, warm spots, and null spots and ...

2011

Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics

Christian Hartinger, Alexey Nazarov, Andrew Douglas Phillips

Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which was evaluated in clinical trials. In this review, we discuss newer developments of polynuclear rut ...

2011

Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin

Paul Joseph Dyson, Olivier Pierre Zava, Michael Groessl

The cellular uptake and subcellular distribution including adduct formation with genomic DNA and uptake into mitochondria of two ruthenium(III)-based drugs in clinical trials, KP1019 and NAMI-A, and cisplatin, was investigated in cisplatin sensitive and re ...

2011

The Therapeutic Efficacy of Camptothecin-Encapsulated Supramolecular Nanoparticles

Li Tang

Nanomaterials have been increasingly employed as drug(s)-incorporated vectors for drug delivery due to their potential of maximizing therapeutic efficacy while minimizing systemic side effects. However, there have been two main challenges for these vectors ...

Elsevier2011

Cell Uptake and Trafficking Behavior of Non-covalent, Coiled-coil Based Polymer-Drug Conjugates

Harm-Anton Klok

This paper reports on the cell uptake and trafficking properties of a series of non-covalent polymer-drug conjugates. These nanomedicines are composed of a poly(N-(2-hydroxypropyl)methacrylamide) backbone functionalized with multiple copies of a drug. The ...

Wiley-Blackwell2011

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Stewart Cole, Joao Pedro De Almeida Neres, Giulia Manina

Summary Tuberculosis is still a leading cause of death in developing countries, for which there is an urgent need for new pharmacological agents. The synthesis of the novel antimycobacterial drug class of benzothiazinones (BTZs) and the identification of t ...

2010

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