Concept

Sweat gland

Related publications (36)

beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells

P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate ...

2007

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma

Johan Auwerx

Steroid receptor coactivator 3 (SRC-3/ACTR/AIB-1/pCIP/RAC3/TRAM-1) is a member of the p160 family of nuclear receptor coactivators that plays an important role in mammary gland growth, development, and tumorigenesis. We show that deletion of SRC-3 gene dec ...

2006

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

Cathrin Brisken

Mammary glands, like other skin appendages such as hair follicles and teeth, develop from the surface epithelium and underlying mesenchyme; however, the molecular controls of embryonic mammary development are largely unknown. We find that activation of the ...

2004

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast

Cathrin Brisken

The mechanisms by which prolactin controls proliferation of mammary epithelial cells (MECs) and morphogenesis of the breast epithelium are poorly understood. We show that cyclin D1(-/-) MECs fail to proliferate in response to prolactin and identify IGF-2 a ...

2002

A paracrine role for the epithelial progesterone receptor in mammary gland development

Cathrin Brisken

Recently generated progesterone receptor (PR)-negative (PR-/-) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. However, the full extent of the mammary gland defec ...

1998

Role of secretory component, a secreted glycoprotein, in the specific uptake of IgA dimer by epithelial cells

Lukas Kühn

The binding of secretory component (SC) to epithelial cells and its role in the specific uptake of immunoglobulin A (IgA) dimer has been studied in rabbit mammary gland and liver. SC, Mr approximately 80,000, secreted by epithelial cells of the mammary gla ...

1979

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