Publications related to Molecular epidemiology

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Martin Kussmann, Sebastiano Collino, Fiona Beguelin

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metab ...

Impact Journals Llc2014

Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function

Beat Fierz, Horst Pick, Sinan Kilic

Patterns of histone post-translational modifications (PTMs) and DNA modifications establish a landscape of chromatin states with regulatory impact on gene expression, cell differentiation and development. These diverse modifications are read out by effecto ...

Elsevier Science Bv2014

Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia

Stewart Cole

Background: Clostridium botulinum and related clostridia express extremely potent toxins known as botulinum neurotoxins (BoNTs) that cause severe, potentially lethal intoxications in humans. These BoNT-producing bacteria are categorized in seven major toxi ...

Public Library of Science2013

Hierarchically Structured Microfibers of ‘Single Stack’ Perylene Bisimide and Quaterthiophene Nanowires

Holger Frauenrath, Roman Niklaus Marty, Ruth Szilluweit, Raffaele Mezzenga

Organic nanowires and microfibers are excellent model systems for charge transport in organic semiconductors under nanoscopic confinement and may be relevant for future nanoelectronic devices. For this purpose, however, the preparation of well-ordered orga ...

Amer Chemical Soc2013

The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community

Martin Kussmann, Ruedi Aebersold

The biology and disease oriented branch of the Human Proteome Project (B/D-HPP) was established by the Human Proteome Organization (HUPO) with the main goal of supporting the broad application of state-of-the-art measurements of proteins and proteomes by l ...

Amer Chemical Soc2013

Molecular basis of telomere syndrome caused by CTC1 mutations

Joachim Lingner, Jana Majerská, Liuh-Yow Chen

Mutations in CTC1 lead to the telomere syndromes Coats Plus and dyskeratosis congenita (DC), but the molecular mechanisms involved remain unknown. CTC1 forms with STN1 and TEN1 a trimeric complex termed CST, which binds ssDNA, promotes telomere DNA synthes ...

Cold Spring Harbor Laboratory Press2013

Mechanisms of LRRK2-Mediated Neurodegeneration

Elpida Tsika, Darren Moore

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common cause of familial Parkinson's disease (PD), whereas common variation at the LRRK2 locus is associated with an increased risk of idiopathic PD. Considerable progress has be ...

Current Science Inc., Springer2012

Sizing Studies for Detecting Graphical Models

Stephan Morgenthaler, Maya Shevlyakova

The ability to identify reliably a positive or negative partial correlation between the expression levels of two genes is determined by the number p of genes, the number n of analyzed samples, and the statistical properties of the measurements. Classical s ...

EPFL STAP2012

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Molecular epidemiology

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function

Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia

Hierarchically Structured Microfibers of ‘Single Stack’ Perylene Bisimide and Quaterthiophene Nanowires

The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Molecular basis of telomere syndrome caused by CTC1 mutations

What have we learned from gene expression profiles in Huntington's disease?

Mechanisms of LRRK2-Mediated Neurodegeneration

Sizing Studies for Detecting Graphical Models

Graph Chatbot

Chat with Graph Search

What have we learned from gene expression profiles in Huntington's disease?

Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Hierarchically Structured Microfibers of ‘Single Stack’ Perylene Bisimide and Quaterthiophene Nanowires

The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community

Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia

Molecular basis of telomere syndrome caused by CTC1 mutations

HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Sizing Studies for Detecting Graphical Models

Mechanisms of LRRK2-Mediated Neurodegeneration