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Concept
Embolization
Summary
Embolization refers to the passage and lodging of an embolus within the bloodstream. It may be of natural origin (pathological), in which sense it is also called embolism, for example a pulmonary embolism; or it may be artificially induced (therapeutic), as a hemostatic treatment for bleeding or as a treatment for some types of cancer by deliberately blocking blood vessels to starve the tumor cells.
In the cancer management application, the embolus, besides blocking the blood supply to the tumor, also often includes an ingredient to attack the tumor chemically or with irradiation. When it bears a chemotherapy drug, the process is called chemoembolization. Transcatheter arterial chemoembolization (TACE) is the usual form. When the embolus bears a radiopharmaceutical for unsealed source radiotherapy, the process is called radioembolization or selective internal radiation therapy (SIRT).
Embolization involves the selective occlusion of blood vessels by purposely introducing emboli, in other words deliberately blocking a blood vessel. Embolization is used to treat a wide variety of conditions affecting different organs of the human body.
Embolization is commonly used to treat active arterial bleeding. Embolization is rarely used to treat venous bleeding as venous bleeding can stop on its own or with packing or compression.
The treatment is used to occlude:
Recurrent coughing up of blood
Cerebral aneurysm
Gastrointestinal bleeding
Nosebleed
Varicocele
Primary post-partum bleeding
Surgical bleeding
Traumatic bleeding such as splenic rupture or pelvic fracture
The treatment is used to slow or stop blood supply thus reducing the size of the tumour:
Kidney lesions
Liver lesions, typically hepatocellular carcinoma (HCC). Treated either by particle infarction or transcatheter arterial chemoembolization (TACE).
Uterine fibroids
Arteriovenous malformations (AVMs)
Arteriovenous fistula
Juvenile Nasopharyngeal Angiofibroma
It could be useful for managing malignant hypertension due to end stage kidney failure.
Official source
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