Concept
Steroid
Related publications (64)
Squalene Depletion in Skin Following Human Exposure to Ozone under Controlled Chamber Conditions
A major component of human skin oil is squalene, a highly unsaturated hydrocarbon that protects the skin from atmospheric oxidants. Skin oil, and thus squalene, is continuously replenished on the skin surface. Squalene is also quickly consumed through reac ...
Amer Chemical Soc2024Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis
Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...
EPFL2022MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly
Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Meltem Weger
The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of mond ...
2020Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids
Florian Frédéric Vincent Breider, Thibault Béranger Masset, Cécilia Laetitia Carla Siri, Yang Liu
Many studies have reported that hydrophobic organic contaminants have the ability to sorb on microplastics in aquatic ecosystem via different mechanisms of sorption. However, a lack of studies investigating desorption of such contaminants in organism fluid ...
2020Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation
A Cu(II)-catalyzed diastereoselective Michael/aldol cascade approach is used to accomplish concise total syntheses of cardiotonic steroids with varying degrees of oxygenation including cardenolides ouabagenin, sarmentologenin, 19-hydroxysarmentogenin, and ...
AMER CHEMICAL SOC2019C/EBP alpha mediates the growth inhibitory effect of progestins on breast cancer cells
Cathrin Brisken, Valentina Scabia
Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide approaches to show that proges ...
WILEY2019Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate. Pa ...
CELL PRESS2019A Short Synthesis of the 2-Bromo-N,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-6-amine Building Block
A concise synthesis of pharmaceutically useful (R)-tert-butyl N-(2-bromo-9-methyl-6,7,8,9-tetrahydro-5H-pyrido [2,3-b ] indol-6-yl) -N-methylcarbamate building block 11 is described. The racemic intermediate 17 was prepared in a single step from 2-bromo-6- ...
AMER CHEMICAL SOC2019Une mesure de la motilité pour analyser le choix modal
Alexis Gumy, Eloi Antoine Maël Bernier
La motilité, définie comme «l’ensemble des caractéristiques propres à un acteur qui permettent d’être mobile» (Kaufmann, 2015), est une notion socio-spatiale qui dépasse aujourd’hui le cadre des analyses sur les différentes formes de mobilité. Dans une var ...
2018An energetic view of stress: Focus on mitochondria
Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is largely derived from mitochondria – unique multifunctional organelles with their own genome. Four main elements connect mitochondria to stress: 1) Energy is r ...
2018