Isotopic labelingIsotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation in neutron count) through a reaction, metabolic pathway, or cell. The reactant is 'labeled' by replacing specific atoms by their isotope. The reactant is then allowed to undergo the reaction. The position of the isotopes in the products is measured to determine the sequence the isotopic atom followed in the reaction or the cell's metabolic pathway.
IsotopologueIn chemistry, isotopologues are molecules that differ only in their isotopic composition. They have the same chemical formula and bonding arrangement of atoms, but at least one atom has a different number of neutrons than the parent. An example is water, whose hydrogen-related isotopologues are: "light water" (HOH or ), "semi-heavy water" with the deuterium isotope in equal proportion to protium (HDO or ), "heavy water" with two deuterium isotopes of hydrogen per molecule ( or ), and "super-heavy water" or tritiated water ( or , as well as and , where some or all of the hydrogen atoms are replaced with the radioactive tritium isotope).
Kinetic isotope effectIn physical organic chemistry, a kinetic isotope effect (KIE) is the change in the reaction rate of a chemical reaction when one of the atoms in the reactants is replaced by one of its isotopes. Formally, it is the ratio of rate constants for the reactions involving the light (kL) and the heavy (kH) isotopically substituted reactants (isotopologues): This change in reaction rate is a quantum mechanical effect that primarily results from heavier isotopologues having lower vibrational frequencies compared to their lighter counterparts.
Atucha Nuclear Power PlantThe Atucha Nuclear Complex, or Atucha Nuclear Power Plant, is the location for two adjacent nuclear power plants in Lima, Zárate, Buenos Aires Province, about from Buenos Aires, on the right-hand shore of the Paraná de las Palmas River. Both are pressurized heavy-water reactors (PHWR) employing a mixture of natural uranium and enriched uranium (0.85% of 235U), and use heavy water for cooling and neutron moderation.
Oxygen-18Oxygen-18 (18O, Ω) is a natural, stable isotope of oxygen and one of the environmental isotopes. 18O is an important precursor for the production of fluorodeoxyglucose (FDG) used in positron emission tomography (PET). Generally, in the radiopharmaceutical industry, enriched water (H218O) is bombarded with hydrogen ions in either a cyclotron or linear accelerator, producing fluorine-18. This is then synthesized into FDG and injected into a patient. It can also be used to make an extremely heavy version of water when combined with tritium (hydrogen-3): 3H218O or T218O.
Oxygen-17Oxygen-17 (17O) is a low-abundance, natural, stable isotope of oxygen (0.0373% in seawater; approximately twice as abundant as deuterium). As the only stable isotope of oxygen possessing a nuclear spin (+5/2) and a favorable characteristic of field-independent relaxation in liquid water, 17O enables NMR studies of oxidative metabolic pathways through compounds containing 17O (i.e. metabolically produced H217O water by oxidative phosphorylation in mitochondria) at high magnetic fields.
Atomic Energy of Canada LimitedAtomic Energy of Canada Limited (AECL) is a Canadian federal Crown corporation and Canada's largest nuclear science and technology laboratory. AECL developed the CANDU reactor technology starting in the 1950s, and in October 2011 licensed this technology to Candu Energy (a wholly owned subsidiary of SNC-Lavalin). AECL describes its goal as ensuring that "Canadians and the world receive energy, environmental and economic benefits from nuclear science and technology – with confidence that nuclear safety and security are assured".
Bruce Nuclear Generating StationBruce Nuclear Generating Station is a nuclear power station located on the eastern shore of Lake Huron in Ontario, Canada. It occupies 932 ha (2300 acres) of land. The facility derives its name from Bruce Township, the local municipality when the plant was constructed, now Kincardine due to amalgamation. With eight CANDU pressurized heavy-water reactors, it was the world's largest fully operational nuclear generating station by total reactor count and the number of currently operational reactors until 2016, when it was exceeded in nameplate capacity by South Korea's Kori Nuclear Power Plant.
