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The formation of the pancreas from the endoderm layer takes place in different steps including the specification of the precursor territory, the outgrowth of pancreas buds, the differentiation of exocrine and endocrine cells, and the migration of endocrine ...
Brain glycogen levels are dynamically regulated by certain neurotransmitters, including noradrenaline (NA) and vasoactive intestinal peptide (VIP). In particular, glycogen synthesis involves activation by NA and VIP of the transcription factors C/EBPbeta a ...
Tissue remodeling often reflects alterations in local mechanical conditions and manifests as an integrated response among the different cell types that share, and thus cooperatively manage, an extracellular matrix. Here we examine how two different cell ty ...
The mechanisms by which the epithelium of the digestive tract and its associated glands are specified are largely unknown. One clue is that several transcription factors are expressed in specific regions of the endoderm prior to and during organogenesis. P ...
During embryonic development, organs arise along the gut tube as a series of buds in a stereotyped anterior-posterior (A-P) pattern. Using chick-quail chimeras and in vitro tissue recombination, we studied the interactions governing the. induction and main ...
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, lep ...
The content of vasoactive intestinal peptide (VIP) was determined by radioimmunoassay in different brain regions of three fish species, namely salmon, trout and carp. The VIP extracted from salmon brain was shown by reverse-phase high-performance liquid ch ...
Microsegregation in a binary alloy solidified in the form of deep cells is predicted using a simplified finite difference model. The model accounts for solid state diffusion and for flow of liquid between cells driven by solidification shrinkage. Cell tip ...
Ontogenic relationships between the different types of endocrine cells in the islets of Langerhans were explored by generating transgenic mouse embryos in which cells transcribing the glucagon, insulin, or pancreatic polypeptide genes were destroyed throug ...
Asymmetry in brain modulation of the immune system has been previously described. In mice, paw preference has been shown to be associated with immune reactivity but the mechanisms involved in such an association are not yet known. The autonomic nervous sys ...
