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My PhD thesis aims to obtain the structure of several bacteriophages, including so-called “jumbo” phages, using the electron cryo-microscopy (cryo-EM) and to study the structural transformation of these viruses as they attach and infect the host cell. We a ...
Viral disinfection kinetics have been studied in depth, but the molecular-level inactivation mechanisms are not understood. Consequently, it is difficult to predict the disinfection behavior of non-culturable viruses, even when related, culturable viruses ...
UV disinfection of viruses frequently leads to tailing after an initial exponential decay. Aggregation, light shielding, recombination or resistant virus sub-populations were proposed as explanations; however, none of these options has conclusively been de ...
Virus removal and inactivation is still a major challenge for water treatment facilities in both industrialised nations and developing countries. This may seem surprising as chlorine disinfection started to spread broadly over a century ago. However, many ...
Human enteric viruses in water sources cause a great public health risk. Conventional disinfection treatments are not able to completely inactive viruses. However, advanced oxidation processes (AOPs) have recently been shown to effectively inactivate patho ...
On-site sanitation technologies such as septic tanks are widely used in low- and middle-income countries. A comprehensive management of the accumulating faecal sludge (FS) is however missing in most contexts and uncontrolled disposal of FS results in serio ...
Water, sanitation and hygiene interventions are among the most significant health interventions addressing the worldwide burden of diarrheal disease and environmental enteropathy. It was recently established that despite an increase in global toilet covera ...
H-1-detected solid-state nuclear magnetic resonance (NMR) experiments are recorded on both intact and trypsin-cleaved sedimented measles virus (MeV) nucleocapsids under ultra-fast magic-angle spinning. High-resolution H-1,N-15-fingerprints allow probing th ...
We study an abstract model for the coevolution between mutating viruses and the adaptive immune system. In sequence space, these two populations are localized around transiently dominant strains. Delocalization or error thresholds exhibit a novel interdepe ...
The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,36 ...