Concept
Oncovirus
Related publications (88)
Comparison of Three Viral Nucleic Acid Preamplification Pipelines for Sewage Viral Metagenomics
Tamar Kohn, Xavier Fernandez Cassi
Viral metagenomics is a useful tool for detecting multiple human viruses in urban sewage. However, more refined protocols are required for its effective use in disease surveillance. In this study, we investigated the performance of three different preampli ...
2024The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
Andrea Ablasser, Baptiste Claude André Guey, Jonathan Jean-Pierre Ricci, Chong Liu, Pauline Ambre Melenec, Pengbiao Xu, Lingyun Li, Ying Liu
Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2 ' 3 '-cyclic GMP-AMP (cGAMP)1-7. The indiscriminate activity of cGAS towards DNA d ...
Nature Portfolio2024A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
Jacques Fellay, Flavia Aurelia Shoko Hodel
Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...
Cambridge2024Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers
Daniele Tavernari, Giovanni Ciriello
Human papillomavirus (HPV) infections are the primary drivers of cervical cancers, and often HPV DNA gets integrated into the host genome. Although the oncogenic impact of HPV encoded genes is relatively well known, the cis-regulatory effect of integrated ...
Hoboken2023Susceptibility of enveloped and non-enveloped viruses to ultraviolet light-emitting diode (UV-LED) irradiation and implications for virus inactivation mechanisms
Ultraviolet (UV) light-emitting diodes (UV-LEDs), a disinfection technology, efficiently inactivate pathogens in water. However, the assessment of UV-LED treatment and the mechanisms of UV inactivation on viruses (especially enveloped viruses) are limited. ...
ROYAL SOC CHEMISTRY2023High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Gerardo Turcatti, Fabien Kuttler
Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- ...
2022Fate of parasites and viruses in calcium hydroxide-treated urine in relation to temperature and moisture content
Human urine can be used as fertilizer and technologies, such as alkaline-urine treatment, are being developed to enable easier re-use. There is, however, a risk of pathogens being present in the urine. This hygiene assessment examined inactivation of three ...
2022Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer model
Gabriele Galliverti, Vincent Roh
High-risk human papillomavirus (HPV) encoding E6/E7-HPV oncogenes are responsible for a subgroup of head and neck squamous-cell carcinoma (HNSCC) and thus therapeutic E7-vaccines may be used to control HPV+HNSCC tumors. Herein we investigated the effects o ...
TAYLOR & FRANCIS INC2021Alfalfa leaf curl virus is efficiently acquired by its aphid vector Aphis craccivora but inefficiently transmitted
Faustine Ambroisine Charline Ryckebusch
Alfalfa leaf curl virus (ALCV) is the first geminivirus for which aphid transmission was reported. Transmission by Aphis craccivora was determined previously to be highly specific and circulative. Using various complementary techniques, the transmission jo ...
MICROBIOLOGY SOC2021Human genomics of the humoral immune response against polyomaviruses
Jacques Fellay, Christian Axel Wandall Thorball, Zhi Ming Xu, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Petar Scepanovic
Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...
OXFORD UNIV PRESS2021