Concept
Two-component regulatory system
Related publications (40)
Evolutionary history expands the range of signaling interactions in hybrid multikinase networks
Anne-Florence Raphaëlle Bitbol, Mohamed Barakat
Two-component systems (TCSs) are ubiquitous signaling pathways, typically comprising a sensory histidine kinase (HK) and a response regulator, which communicate via intermolecular kinase-to-receiver domain phosphotransfer. Hybrid HKs constitute non-canonic ...
NATURE RESEARCH2021Phosphoregulated orthogonal signal transduction in mammalian cells
Orthogonal tools for controlling protein function by post-translational modifications open up new possibilities for protein circuit engineering in synthetic biology. Phosphoregulation is a key mechanism of signal processing in all kingdoms of life, but too ...
2020Mechanomicrobiology: how bacteria sense and respond to forces
Microbiology and biophysics are converging to advance our understanding of the mechanobiology of microorganisms. In this Review, Dufrene and Persat discuss the physical forces that bacteria experience in their natural environments and the structures that t ...
NATURE PUBLISHING GROUP2020Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase
Matteo Dal Peraro, Luciano Andres Abriata
Environmental awareness is an essential attribute of all organisms. The homeoviscous adaptation system of Bacillus subtilis provides a powerful experimental model for the investigation of stimulus detection and signaling mechanisms at the molecular level. ...
American Society for Microbiology2019Association of Both Inhibitory and Stimulatory G alpha Subunits Implies Adenylyl Cyclase 5 Deactivation
Ursula Röthlisberger, Siri Camee van Keulen, Daniele Narzi
Adenylyl cyclase (AC) generates cyclic AMP required for a variety of cellular functions, and its regulation plays a major role in cellular signal transduction in eukaryotes and prokaryotes. All membrane-bound AC isoforms in eukaryotes can be activated by s ...
AMER CHEMICAL SOC2019Computational design of G Protein-Coupled Receptor allosteric signal transductions
Patrick Daniel Barth, Dániel Kéri
Membrane receptors sense and transduce extracellular stimuli into intracellular signaling responses but the molecular underpinnings remain poorly understood. We report a computational approach for designing protein allosteric signaling functions. By combin ...
2019Redox Signaling by Reactive Electrophiles and Oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and mul ...
2018A systems perspective on brown adipogenesis and metabolic activation
Bart Deplancke, Magda Zachara, Rachana Narendra Pradhan
Brown adipocytes regulate energy expenditure via mitochondrial uncoupling. This makes these fat cells attractive therapeutic targets to tackle the burgeoning issue of obesity, which itself is coupled to insulin resistance, type 2 diabetes, cardiovascular a ...
Wiley-Blackwell2017Inferring interaction partners from protein sequences
Anne-Florence Raphaëlle Bitbol
Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multiprotein complexes and to enable signal transduction in various pathways. Functional interactions between proteins result in coevolution betwee ...
Proceedings of the National Academy of Sciences2016Identification of genetic interactors of ypa2 in Schizosaccharomyces pombe
In this study, the fission yeast Schizosaccharomyces pombe was used as a model system to study the cellular signaling that underlies cell cycle progression. Phosphorylation plays an important part in the regulation of this process. Kinases catalyze the tra ...
EPFL2016