Concept

Senescence

Related publications (74)

Cold-Inducible RNA-Binding Protein Modulates Circadian Gene Expression Posttranscriptionally

In mammalian tissues, circadian gene expression can be driven by local oscillators or systemic signals controlled by the master pacemaker in the suprachiasmatic nucleus. We show that simulated body temperature cycles, but not peripheral oscillators, contro ...

American Association for the Advancement of Science2012

Naphthalimide-tagged ruthenium-arene anticancer complexes: combining coordination with intercalation

Paul Joseph Dyson, Catherine Marie Amélie Clavel, Fabio Edafe, Kelly Joan Kilpin

Ruthenium(II) arene compounds have been modified with the naphthalimide group, tethered via the arene ligand, i.e. {dichloroeta(6)-N-(phenylalkyl)(4-dimethylamino)-1,8-naphthalimideruthenium(II)} (alkyl = methyl, ethyl, propyl, pta = 1,3,5-triaza-7- ...

American Chemical Society2012

The metabolic footprint of aging in mice

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Raphaël Doenlen, Richardus Houtkooper, Ellen Helena Jeninga

Aging is characterized by a general decline in cellular function, which ultimately will affect whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, metabolic dysfunction is a common hallmark of aging at least in inverte ...

2011

Fatigue life prediction of composite materials under realistic loading conditions (variable amplitude loading)

Two of the most widely used methods for the fatigue life prediction of composite materials under variable amplitude (VA) loading patterns are presented in this chapter. The first method is based on the theoretical formulation and use of a damage summation ...

Woodhead Publishing2010

Ppargamma2 is a key driver of longevity in the mouse

Johan Auwerx

Aging involves a progressive physiological remodeling that is controlled by both genetic and environmental factors. Many of these factors impact also on white adipose tissue (WAT), which has been shown to be a determinant of lifespan. Interrogating a trans ...

Public Library of Science2009

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

Johan Auwerx

The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a Pro12Ala knockin model, that on chow diet, Ala/Ala mice are le ...

2009

Verification of Aging Faces Using Local Ternary Patterns and Q-Stack Classifier

Andrzej Drygajlo, Weifeng Li

This paper deals with the influence of age progression on the performance of face verification systems. This is a challenging and largely open research problem that deserves more and more attention. Aging affects both the shape of the face and its texture, ...

Springer2009

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

Maike Jaworski

Cell-intrinsic checkpoints limit the proliferative capacity of primary cells in response to telomere dysfunction. It is not known, however, whether telomere dysfunction contributes to cell-extrinsic alterations that impair stem cell function and organ home ...

2007

Human telomerase RNA accumulation in cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

Joachim Lingner, Katarzyna Sikora

Telomerase is required for telomere maintenance and is responsible for the immortal phenotype of cancer cells. How telomerase is assembled and reaches telomeres in the context of nuclear architecture is not understood. Recently, the telomerase RNA subunit ...

2007

Telomere length homeostasis requires that telomerase levels are limiting

Joachim Lingner

Stabilization of telomere length in germline and highly proliferative human cells is required for long-term survival and for the immortal phenotype of cancer-derived cells. This is achieved through expression of telomerase reverse transcriptase (TERT), whi ...

2006

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