Concept

Bone remodeling

Related publications (76)

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast activity ...

Public Library of Science2014

Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty

Dominique Pioletti, Alexandre Terrier, Brigitte Jolles-Haeberli, Alireza Roshan Ghias

Bone defects in revision knee arthroplasty (RKA) are often located in load-bearing regions. The goal of this study was to determine if a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to a ...

Taylor & Francis2014

Synaptic Plasticity and the Warburg Effect

Pierre Magistretti

Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with ...

Elsevier2014

3D Assessment of Mandibular Growth Based on Image Registration: A Feasibility Study in a Rabbit Model

Background. Our knowledge of mandibular growth mostly derives from cephalometric radiography, which has inherent limitations due to the two-dimensional (2D) nature of measurement. Objective. To assess 3D morphological changes occurring during growth in a r ...

Hindawi Publishing Corporation2014

Integration of mechanotransduction concepts in bone tissue engineering

Dominique Pioletti

Mechanical stimulus has been identified for a long time as a key player in the adaptation of the musculo-skeletal tissues to their function. Mechanical loading is then an intrinsic variable to be considered when new developments are proposed in bone tissue ...

Taylor & Francis2013

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

Implementation of the "loaded implant" model in the rat using a miniaturized setup - description of the method and first results

John Botsis, Joël Cugnoni, Philippe Bonhote

Objective To miniaturize the loaded implant model to permit its application to small rodents. In this model, two titanium implants are placed 8 mm apart with their heads protruding from the skin and are forced together by a dedicated actuator. To assess th ...

Wiley-Blackwell2012

Prediction of spatio-temporal bone formation in scaffold by diffusion equation

Dominique Pioletti, Arne Christian Vogel, Lalaonirina Rakotomanana Ravelonarivo, Alireza Roshan Ghias

Developing a successful bone tissue engineering strategy entails translation of experimental findings to clinical needs. A major leap forward towards this goal is developing a quantitative tool to predict spatial and temporal bone formation in scaffold. We ...

2011

In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates

Dominique Pioletti, Alireza Roshan Ghias

A successful bone tissue engineering strategy entails producing bone-scaffold construct with adequate mechanical properties. Apart from the mechanical properties of the scaffold itself, the forming bone inside the scaffold also adds to the strength of the ...

2011

Biomechanical Aspects of Osteogenesis in Load-Bearing Tissue Engineering Scaffolds

Alireza Roshan Ghias

There is increasing evidence that mechanical stimulation affects the fate of tissue engineering scaffolds. In clinical situations, it is critical to accelerate bone formation inside the scaffold to reduce the recovery time and increase the chance of succes ...

EPFL2011

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