Publications related to Coronary circulation

Angiotensin II infusion into ApoE(-/-) mice: a model for aortic dissection rather than abdominal aortic aneurysm?

Nikolaos Stergiopoulos, Lydia Aslanidou, Jessica Sordet, Bram Trachet, Alessandra Piersigilli, Patrick Segers

Aims Angiotensin II-infused ApoE(-/-) mice are a popular mouse model for preclinical aneurysm research. Here, we provide insight in the often-reported but seldom-explained variability in shape of dissecting aneurysms in these mice. Methods and results N=45 ...

2017

Influence of Vascular Variant of the Posterior Cerebral Artery (PCA) on Cerebral Blood Flow, Vascular Response to CO2 and Static Functional Connectivity

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Daniela Maria Zöller, Kirsten Emmert

Introduction The fetal origin of the posterior cerebral artery (fPCA) is a frequent vascular variant in 11-29% of the population. For the fPCA, blood flow in the PCA originates from the anterior instead of the posterior circulation. We tested whether this ...

Public Library of Science2016

MATHICSE Technical Report : A fast virtual surgery platform for many scenarios haemo-dynamics of patient-specific coronary artery bypass grafts

Alfio Quarteroni, Gianluigi Rozza, Andrea Manzoni, Elena Faggiano

A fast computational framework is devised to the study of several configurations of patient-specific coronary artery by-pass grafts. This is especially useful to perform a sensitivity analysis of the haemodynamics for different flow conditions occurring in ...

MATHICSE2016

Ascending Aortic Aneurysm in Angiotensin II–Infused Mice: Formation, Progression, and the Role of Focal Dissections

Nikolaos Stergiopoulos, Lydia Aslanidou, Jessica Sordet, Bram Trachet, Alessandra Piersigilli, Patrick Segers

Objective To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-infused ApoE(-/-) mice. Approach and Results We combined an extensive in vivo imaging protocol (high-frequency ultrasound and contrast-enhanced microcomputed ...

2016

Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations

Bram Trachet, Patrick Segers

The ApoE(-/-) mouse is a common small animal model to study atherosclerosis, an inflammatory disease of the large and medium sized arteries such as the carotid artery. It is generally accepted that the wall shear stress, induced by the blood flow, plays a ...

Elsevier Sci Ltd2016

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Demetri Psaltis, Donald Benjaman Conkey, Thomas Jean Victor Marie Lanvin, Laurent Descloux

Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and ...

Spie-Int Soc Optical Engineering2015

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Rolf Gruetter, Hongxia Lei, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Elsevier2015

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Nikolaos Stergiopoulos, Bram Trachet, Patrick Segers

Recent research has revealed that angiotensin II-induced abdominal aortic aneurysm in mice can be related to medial ruptures occurring in the vicinity of abdominal side branches. Nevertheless a thorough understanding of the biomechanics near abdominal side ...

Springer2015

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Jean Louis Raisaro

According to many scientists and clinicians, genomics is the "next big thing" in the field of medicine. On one hand, decreasing costs in genome sequencing has been paving the way to better preventive and personalized medicine. On the other hand, genomic da ...

2013

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Coronary circulation

Angiotensin II infusion into ApoE(-/-) mice: a model for aortic dissection rather than abdominal aortic aneurysm?

Influence of Vascular Variant of the Posterior Cerebral Artery (PCA) on Cerebral Blood Flow, Vascular Response to CO2 and Static Functional Connectivity

MATHICSE Technical Report : A fast virtual surgery platform for many scenarios haemo-dynamics of patient-specific coronary artery bypass grafts

Experimental Testing of AF Septal Modeling Results

Ascending Aortic Aneurysm in Angiotensin II–Infused Mice: Formation, Progression, and the Role of Focal Dissections

Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data

Graph Chatbot

Chat with Graph Search

Experimental Testing of AF Septal Modeling Results

Influence of Vascular Variant of the Posterior Cerebral Artery (PCA) on Cerebral Blood Flow, Vascular Response to CO2 and Static Functional Connectivity

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data

Angiotensin II infusion into ApoE(-/-) mice: a model for aortic dissection rather than abdominal aortic aneurysm?

MATHICSE Technical Report : A fast virtual surgery platform for many scenarios haemo-dynamics of patient-specific coronary artery bypass grafts

Ascending Aortic Aneurysm in Angiotensin II–Infused Mice: Formation, Progression, and the Role of Focal Dissections

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance