Publications related to Protein phosphorylation

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

Jürgen Brugger, Kristopher Pataky

53BP1, the vertebrate ortholog of the budding yeast Rad9 and fission yeast Crb2/Rhp9 checkpoint proteins, is recruited rapidly to sites of DNA double-strand breaks (DSBs). A tandem tudor domain in human 53BP1 that recognizes methylated residues in the hist ...

2009

Transmission and spreading of tauopathy in transgenic mouse brain

Tristan Bolmont

Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease(1). In the disease process, neuronal tau inclusions first appear in the transentorhinal cortex from where they se ...

Nature Publishing Group2009

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

Hilal Lashuel

In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recess ...

Public Library of Science2009

Structure and function of the molecular chaperone Hsp104 from yeast

Hilal Lashuel

The molecular chaperone Hsp104 plays a central role in the clearance of aggregates after heat shock and the propagation of yeast prions. Hsp104's disaggregation activity and prion propagation have been linked to its ability to resolubilize or remodel prote ...

Wiley-Blackwell2009

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein

Hilal Lashuel, Adrian Schmid, Magdalena Zweckstetter

alpha-Synuclein (alpha-syn) phosphorylation at serine 129 is characteristic of Parkinson disease (PD) and related alpha-synulceinopathies. However, whether phosphorylation promotes or inhibits alpha-syn aggregation and neurotoxicity in vivo remains unknown ...

American Society for Biochemistry and Molecular Biology2008

Protein kinases of malaria parasites: an update

Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the past few years, in part as a consequence of the realization that PKs repr ...

Elsevier2008

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

Malaria is a major threat to world health. The identification of parasite targets for drug development is a priority and parasitic protein kinases suggest themselves as suitable targets as many display profound structural and functional divergences from th ...

2008

Specific On-Plate Enrichment of Phosphorylated Peptides for Direct MALDI-TOF MS Analysis

Hubert Girault, Christophe Roussel, Liang Qiao, Jingjing Wan

An on-plate specific enrichment method is presented for the direct analysis of peptides phosphorylation. An array of sintered TiO2 nanoparticle spots was prepared on a stainless steel plate to provide porous substrate with a very large specific surface and ...

American Chemical Society2007

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

Stewart Cole, Pablo Fernandez

Reversible protein phosphorylation is a major regulation mechanism of fundamental biological processes, not only in eukaryotes but also in bacteria. A growing body of evidence suggests that Ser/Thr phosphorylation play important roles in the physiology and ...

2007

Protein phosphorylation

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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

Transmission and spreading of tauopathy in transgenic mouse brain

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

Structure and function of the molecular chaperone Hsp104 from yeast

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein

Protein kinases of malaria parasites: an update

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

Specific On-Plate Enrichment of Phosphorylated Peptides for Direct MALDI-TOF MS Analysis

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

Structure and function of the molecular chaperone Hsp104 from yeast

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein

Protein kinases of malaria parasites: an update

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

Transmission and spreading of tauopathy in transgenic mouse brain

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential

Specific On-Plate Enrichment of Phosphorylated Peptides for Direct MALDI-TOF MS Analysis