Concept

Computational biology

Related publications (422)

LaMBERT: Light and Multigranular BERT

Pre-training complex language models is essential for the success of the recent methods such as BERT or OpenAI GPT. Their size makes not only the pre-training phase, but also consecutive applications to be computationally expensive. BERT-like models excel ...

2020

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Matthias Lütolf, Nathalie Brandenberg, Yoji Tabata, Nikolche Gjorevski, Mikhail Nikolaev, Nicolas Antoine Vincent Broguiere, Olga Mitrofanova, Devanjali Dutta

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology(1-4). However, the approaches that are used at present to derive these organoids in three-dimensional matrices(5,6)r ...

NATURE PUBLISHING GROUP2020

Hybrid high-resolution RBF-ENO method

Jan Sickmann Hesthaven, Fabian Mönkeberg

Essentially nonoscillatory (ENO) and weighted ENO (WENO) methods on equidistant Cartesian grids are widely used to solve partial differential equations with discontinuous solutions. The RBF-ENO method is highly flexible in terms of geometry, but its stenci ...

2020

Assessing Cu2L2X4 dimeric moieties as ferromagnetic building blocks in double halide-bridged polymers (X = Cl-, Br- and L = benzamide). An experimental and computational study

Two isostructural double halide-bridged polymers, consisting of stacked Cu2L2X4 dimers, with L = benzamide (BA) and X = Cl- in CuClBA and X = Br- in CuBrBA, were synthesised. The experimental magnetic data of both compounds were recorded and it was found t ...

2020

Low-dimensional firing-rate dynamics for populations of renewal-type spiking neurons

Tilo Schwalger

The macroscopic dynamics of large populations of neurons can be mathematically analyzed using low-dimensional firing-rate or neural-mass models. However, these models fail to capture spike synchronization effects and nonstationary responses of the populati ...

AMER PHYSICAL SOC2020

PolyMPC: An efficient and extensible tool for real-time nonlinear model predictive tracking and path following for fast mechatronic systems

Colin Neil Jones, Petr Listov

This paper presents PolyMPC, an open-source C++ library for pseudospectral-based real-time predictive control of nonlinear systems. It provides a necessary background on the computational aspects of the pseudospectral approximation of optimal control probl ...

WILEY2020

PolyMPC: An efficient and extensible tool for real‐time nonlinear model predictive tracking and path following for fast mechatronic systems

Colin Neil Jones, Petr Listov

This paper presents PolyMPC, an open‐source C++ library for pseudospectral‐based real‐time predictive control of nonlinear systems. It provides a necessary background on the computational aspects of the pseudospectral approximation of optimal control probl ...

2020

Gender medicine and oncology: report and consensus of an ESMO workshop

Jacques Fellay

Background: The importance of sex and gender as modulators of disease biology and treatment outcomes is well known in other disciplines of medicine, such as cardiology, but remains an undervalued issue in oncology. Considering the increasing evidence for t ...

OXFORD UNIV PRESS2019

Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity

Yimon Aye, Xuyu Liu

Here we discuss, how by applying chemical concepts to biological problems, methods have been developed to map spatiotemporal regulation of proteins and small-molecule modulation of proteome signaling responses. We outline why chemical-biology platforms are ...

2019

Chapter 16: Microbial Production of Flavonoids: Engineering Strategies for Improved Production

Edgard Gnansounou, Binod Parameswaran

Flavonoids are natural plant-derived compounds which have immense applications in pharmaceutical industry and have attracted the attention of both the industry and researchers involved in all fields of biology and medicine. Microbial production systems can ...

Wiley2019

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.