Concept

Elastic fiber

Related publications (33)

Model-based estimation of active knee stiffness

Knee joint impedance varies substantially during physiological gait. Quantifying this modulation is critical for the design of transfemoral prostheses that aim to mimic physiological limb behavior. Conventional methods for quantifying joint impedance typic ...

2011

Formation of the Long Range Dpp Morphogen Gradient

Sascha Dalessi, Markus Affolter

The TGF-β homolog Decapentaplegic (Dpp) acts as a secreted morphogen in the Drosophila wing disc, and spreads through the target tissue in order to form a long range concentration gradient. Despite extensive studies, the mechanism by which the Dpp gradient ...

2011

Arterial remodeling using a constituent-based approach

Alkiviadis Tsamis

This thesis is intended to contribute to the field of biomechanics of growth and remodeling of arteries. The work focuses particularly on growth and remodeling caused by sustained hypertension, increased blood flow, and ageing. A structure-based constituti ...

EPFL2010

Effect of aging on elastin functionality in human cerebral arteries

Michaël Unser, Nikolaos Stergiopoulos, Daniel Sage, Edouard Fonck, Jean Fasel

Aging affects elastin, a key component of the arterial wall integrity and functionality. Elastin degradation in cerebral vessels is associated with cerebrovascular disease. The goal of this study is to assess the biomechanical properties of human cerebral ...

ASA2009

A three-dimensional elastic plastic damage constitutive law for bone tissue

Alain Curnier

Motivated by mechanical analysis of bones and bone-implant systems, a 3D constitutive law describing the macroscopic mechanical behaviour of both cortical and trabecular bone in cyclic (not fatigue) overloads is developed. The proposed model which mathemat ...

Springer Verlag2009

On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall

Nikolaos Stergiopoulos, Sylvain Roy, Alkiviadis Tsamis, Gilles Prod'Hom

Earlier experimental work on decellularized arteries revealed the existence of significant residual stresses within the arterial wall, which are released upon chemical removal of vascular smooth muscle in normal arteries causing substantial radial expansio ...

2008

Biomechanical analysis of cerebral arteries

Edouard Fonck

The intent of this thesis is to study the function of elastin in cerebral arteries, its contribution into the aging process and its implication into different cerebral diseases and in particular cerebral aneurysms. As of today, little is known on the genes ...

EPFL2008

Effect of elastin degradation on carotid wall mechanics as assessed by a constituent-based biomechanical model

Nikolaos Stergiopoulos, Sylvain Roy, Luca Augsburger, Edouard Fonck, Gilles Prod'Hom

Arteries display a nonlinear anisotropic behavior dictated by the elastic properties and structural arrangement of its main constituents, elastin, collagen, and vascular smooth muscle. Elastin provides for structural integrity and for the compliance of the ...

2007

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

Jean-Jacques Meister, Boris Hinz, Pierre Jean Arnould Wipff

The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts a ...

Rockefeller University Press2007

Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures

Melody Swartz

Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and ...

Springer US2006

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