Concept
Biological target
Related people (32)
John McKinney
Professor John McKinney received his Ph.D. from The Rockefeller University (New York, NY) in 1994 for studies on cell cycle regulation in
Saccharomyces cerevisiae
in the laboratory of Fred Cross. From 1995 to 1998, he was a postdoctoral fellow in the laboratory of William Jacobs at the Albert Einstein College of Medicine (Bronx, NY), where he studied mechanisms of persistence in
Mycobacterium tuberculosis
. In 1999, he returned to Rockefeller University to establish his own laboratory as an Assistant (1999-2004) and then Associate (2004-2007) Professor. In July 2007, the lab relocated to the Global Health Institute in the School of Life Sciences at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where McKinney is Professor and Head of the Laboratory of Microbiology and Microsystems (LMIC). Our research focuses on understanding the mechanistic basis of bacterial persistence in the context of host immunity and antimicrobial therapy, using
M. tuberculosis
as a "model" system.
Sandrine Gerber
Sandrine Gerber studied chemistry at the "Ecole Nationale Supérieure de Chimie de Paris" in France, where she obtained a diploma of chemical engineer in 1993. The same year she obtained a DEA (Master degree) of organic chemistry at the University Pierre et Marie Curie (Paris VI, France). From 1993 to 1996 she did a PhD in organic chemistry under the supervision of Prof. Jean-Pierre Genêt at the Ecole Nationale Supérieure de Chimie de Paris. In 1996, she moved to University of Lausanne for a post-doctoral stay under the supervision of Prof. Pierre Vogel. In 1998, she was appointed Maître-Assistante at the Institute of Organic Chemistry in the University of Lausanne. In 2003, she obtained the habilitation to direct research from the University Pierre et Marie Curie (Paris VI, France). The same year, she was appointed scientific adjunct at the EPFL and senior scientist (Maître d'Enseignement et de Recherche) in 2006. In December 2014, she was promoted to titular professor. Since September 2007, Sandrine Gerber is deputy to the director of the Institute of Chemical Sciences and Engineering (ISIC). She is also member of the Board of Directors of the Swiss Chemical Society. Since 2007, Sandrine Gerber is part-time lecturer at the university of Fribourg. She was awarded the Prize Eugene Schueller in 1997, the Prize Dufour for prospective organic chemistry in 2005 and the Werner Prize 2010. She also received a special mention in recognition of exceptional quality of pedagogic competencies in the teaching of basic sciences, given by the Direction of the School of Biology and Medicine from the University of Lausanne, in 2013. In October 2018, she will receive the Prize for Excellence in Teaching from the section of Chemistry and Chemical Engineering.
Hilal Lashuel
2012-2013 Visiting Professor, Standford University. Stanford School of Medicine
2011- Associate Professor of Life Sciences-Brain Mind Institute-EPFL
Dir. Laboratory of Chemical Biology of Neurodegeneration
2005-2011 Assistant Professor of Life Sciences-Brain Mind Institute-EPFL
Dir. Laboratory of Molecular Neurobiology and Neuroproteomics
2005-2008 Director- EPFL Proteomic Core Facility
2002-2004 Instructor of Neurology- Harvard Medical School and Brigham and Women's
Hospital
2001-2002 Sabbatical Fellow- Laboratory for Drug Discovery in Neurodegeneration
Harvard Medical School,
2001-2002 Post-doctoral Fellow- Center for Neurologic Diseases
Harvard Medical School and Brigham and Women's Hospital
Advisor- Prof. Peter T. Lansbury
2000-2001 Research Scientist, The Picower Institute for Medical Research, Great Neck
New York
1994-2000 PhD Student; Texas A&M University and the Scripps Research Institute
Advisor- Prof. Jeffery W. Kelly
1990-1994 B.S. City University of New York, Brooklyn College
Dr. Hilal A. Lashuel received his B.Sc. degree in chemistry from the City University of New York in 1994 and completed his doctoral studies at Texas A&M University and the Scripps Research Institute in 2000. After obtaining his doctoral degree, he became a research fellow at the Picower Institute for Medical Research in Long Island New York. In 2001, he moved to Harvard Medical School and the Brigham and Women's Hospital as a research fellow in the Center for Neurologic Diseases and was later promoted to an instructor in neurology at Harvard Medical School. During his tenure (2001-2004) at Harvard Medical School his work focused on understanding the mechanisms of protein misfolding and fibrillogenesis and the role of these processes in the pathogenesis of Parkinson's and Alzheimer's disease. In 2005 Dr. Lashuel moved Switzerland to join the Brain Mind Institute at the Swiss Federal Institute of Technology Lausanne as a tenure-track assistant professor in neurosciences. Currently, Dr. Lashuel is an associate professor of life sciences and the director of the laboratory of molecular and chemical biology of neurodegeneration. (http://lashuel-lab.epfl.ch/).
Research efforts in the Lashuels laboratory focus on understanding the molecular mechanisms of neurodegeneration and developing novel strategies to diagnose and treat neurodegenerative diseases such as Alzheimers and Parkinsons disease. Research in the Lashuel lab is funded by several international funding agencies and foundations, including the Swiss National Science Foundation, European FP7 program (Marie Curie and ERC grants), Human Science Frontiers, Strauss Foundation, Cure the Huntingtons disease foundation and Michael J Fox foundation and is supported by collaborations with pharmaceutical and biotech companies (http://lashuel-lab.epfl.ch/page-50538-en.html), Nestle, Merck-Serono, AC Immune and Johnson and Johnson.
Dr. Lashuels research has resulted in the characterization of novel quaternary structure intermediates on the amyloid pathway, identification of potential therapeutic targets, and new hypotheses concerning the mechanisms of pathogenesis in Alzheimers disease, Parkinsons disease and related disorders. Dr. Lashuel scientific contribution to this field includes i) more than100 publications in major peer reviewed journals including Nature journals, Cell, PNAS, JBC, J. Neuroscience JACS, and Angewandtie Chemie; ii) three patents on novel strategies for preventing protein aggregation and treating autoimmune and inflammatory diseases; iii) more than 150 invited lectures since 2002 and more than 5500 citations (7800 citation-Google Scholar) since 1996. Dr. Lashuel has received several pre-doctoral and post-doctoral awards and fellowships and was the recipient of two prestigious awards given to young investigators; Human Science Frontiers young investigator research award and the European Research Council (ERC) starting independent researcher grant and the ERC proof of concept award (2013) These awards provide more than $2.5 Million to Dr. Lashuel to translate some of his ideas and projects into novel strategies for diagnosing and treating neurodegenerative diseases such as Alzheimers and Parkinsons disease. Dr. Lashuel has chaired and co-organized several international conferences and serves as an academic editor for PLoS ONE, an associate editor for frontiers of molecular neuroscience, member of the Editorial advisory board of ChemBioChem and ad hoc reviewer for several international scientific journals and funding agencies.
Urs von Gunten
URS VON GUNTEN
born in Baden (Switzerland) on 20/10/1959
RESEARCH INTERESTS
Drinking water quality and water treatment. Unit processes and process combinations (adsorption processes, membrane processes, oxidation processes). Chemical oxidation and advanced oxidation processes: kinetics and mechanisms of formation of disinfection by-products and degradation of micropollutants. Assessment of toxicology of of transformation products. Biogeochemical processes in riverbank filtration systems. In situ and out-of-ground treatment of groundwaters
EDUCATION
Diploma Swiss Federal Institute of Technology (ETH) Zürich, Department of Chemistry,Switzerland, 1983
Ph.D.Swiss Federal Institute of Technology (ETH) Zürich, Switzerland, 1989.
AWARDS AND FELLOWSHIPS
2018 Clarivate Analytics Highly Cited Researcher
2015 Thomson Reuters Highly Cited Researcher
2015 Recipient of the Harvey Rosen Award 2015 of the International Ozone Association
2015 Professorship under the Chinese Academy of Sciences President’s International Fellowship Initiative for Distinguished Scientists
2014 Thomson Reuters Highly Cited Researcher
2013 Distinguished Lecturer for AEESP at the American Water Works Association Annual Conference, Denver, June 10, 2013
2012-to date Adjunct Professor at the Gwangju Institute of Science and Technology, Korea
2011 Full Professor at the Swiss Federal Institute of Technology, Lausanne (EPFL)
2010 Adjunct Professor at the State Key Laboratory of Environmental Aquatic
Chemistry, Chinese Academy of Sciences
2010 Adjunct Professor at the Curtin University of Technology, Perth,
Australia
2007 Honorary Professorship at the Harbin Institute of Technology, Harbin,
China
2007 Recipient of the Harvey Rosen Award 2007 of the International Ozone
Association
2007 Environmental Science and Technology Excellence in Review Award
2006 Professor title at ETHZ, Department of Environmental Sciences
2001 Recipient of the Harvey Rosen Award 2001 of the International Ozone
Association
1999 Recipient of the Marteen Schalekamp Award 1999 of the IWSA
1993 Recipient of a short-term fellowship of the Swiss National Science
Foundation in 1993 and 1994
1993 EERO short-term fellowship-holder
PROFESSIONAL RECORD
2013-2016 Head of transdisciplinary project “Regional Water Supply Basel Country 21”, Eawag
2010-2017 Head of Competence Center for Drinking Water, Eawag
2008/2009 Visiting Professor at the Curtin Water Quality Research Centre,
Curtin University of Technology, Perth, Australia
2004-to date Deputy head of department Water Resources and Drinking Water,
Eawag
2004-2008 Head of the cross-cutting project Drinking water for the 21st
century, Eawag
2000 2004 Head of department Water Resources and Drinking Water, Eawag
2000/2001 Sabbatical at University of Colorado, Boulder
1998 - 1999 Head of department of Chemistry, Eawag
1995 - 2011 Lecturer at Swiss Federal Institute of Technology (ETH) Zürich,
Switzerland.
1995- to date Group leader of the drinking water group of the chemistry
department at Eawag
1994/93 Visiting Scientist at the International Research Center for
Water and Environment of Lyonnaise des Eaux (8 months),
CIRSEE, Le Pecq, France
since 1992 Research Scientist at Eawag
1989 - 1991 Postdoctoral Researcher at Eawag
1984 - 1989 Research Assistant, Swiss Federal Institute of Technology,
Zürich
EDITORIAL ACTIVITIES
Associate Editor Environmental Science and Technology (2010/2011)
Guest Editor Water Research for special issue on Emerging
Contaminants (2010)
Guest Editor Journal of water supply: Research and
Technology-Aqua for a special issue on Oxidation Processes (2008)
Member of the editorial board of the journal Ozone: Science and Engineering.
Member of the editorial board of Journal of water supply: Research and Technology-Aqua.
FORMER PROFESSIONAL ACTIVITIES
2016 Co-organizer of PEAK seminar ”Neue Herausforderungen und Lösungsansätze in der Wasserversorgung – Fallbeispiele aus dem Kanton BL”. Dübendorf, November 11, 2016
2015 Organizer of PEAK seminar “Micropollutants in drinking water”, Dübendorf, October 30
2014 Co-organizer of the Eawag Infotag “Wasserversorgung und Uferfiltration – ein System unter Druck?” Dübendorf, September 9, 2014
2014 Co-organizer of a Symposium “Advanced oxidation processes for water treatment” 5th EuCheMS Chemistry Congress 2014, Aug. 31 – Sept. 4, Istanbul, Turkey, 2014
2013 Co-Organizer of PEAK seminar on “Oxidation and Disinfection Processes”, Aug. 30, Dübendorf
2013 Co-Organizer of the Micropoll & Ecohazard Conference, Zürich, June 17-19, 2013
2013 Co-Organizer of the session “Advanced Oxidation – Technologies and Applications, Leading Edge Technology (LET) Conference, Bordeaux, June 2-6, 2013
2011 Co-Organizer of Korean-Swiss Science Days in Zürich “Water for the Future”, ETHZ, November 9-10, 2011.
2010 Co-Organizer of an international symposium “Oxidation processes in natural and technical aquatic systems” in honour of Jürg Hoigné’s 80 birthday, Eawag, May 21, 2010.
2010 Co-Organizer of 23. Mülheimer Wassertechnisches Seminar “Möglichkeiten und Grenzen von oxidativen Prozessen in der Wasserreinhaltung”, March 11, 2010, IWW, Mülheim an der Ruhr
2008 Co-Organizer of the Eawag Infotag 2008 “Vom Gewässer ins Glas”, Sept. 12, 2008, Eawag, Dübendorf
2008 Organizing committee of Leading Edge Technology Conference (LET), Zürich, June 1-4, 2008.
2008 Co-organizer of Sino-Swiss workshop “Water Resources Management and Drinking Water Quality”, Harbin Institute of Technology, Harbin, China, January, 2008
2007 Organizer of Wave21 seminar on “New insights in the field of drinking water treatment”, Dübendorf, Sept. 14, 2007.
2007 Co-organizer of a symposium entitled “Sustainability in Water Supply: Advances in Oxidation Processes for Water Treatment” at ACS Spring conference, Chicago, March 25-29, 2007.
2006 Organizer of Wave21 seminar on “New developments of analytical methods for drinking water analysis”, Dübendorf, Sept. 15, 2006,
2005 Organizer of Wave21 seminar on “New applications of ozone in water treatment”, Sept. 23, 2005, Dübendorf
1999 Co-organizer of 200th Anniversary Symposium in honor of Ch. F. Schönbein - the discoverer of ozone, October 1999, Basel.
1995 Organizer of a symposium in honor of J. Hoigné, June, 1995, Dübendorf, Switzerland
1991 Co-organizer of the workshop "Chemodynamics of Groundwaters", November, 1991, Mont Sainte-Odile, France