Publications related to Epigenome

Mitotic chromosome binding predicts transcription factor properties in interphase

David Michael Suter, Cédric Deluz, Torgil Elias Friman, Andrea Brigitta Alber, Mahé Cécile Raccaud

Mammalian transcription factors (TFs) differ broadly in their nuclear mobility and sequence-specific/non-specific DNA binding. How these properties affect their ability to occupy specific genomic sites and modify the epigenetic landscape is unclear. The as ...

2019

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Douglas Hanahan, Mohammad Sadegh Saghafinia, Giovanni Ciriello, Marco Mina

The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...

CELL PRESS2018

Gene regulatory mechanisms underlying the intestinal innate immune response

Bart Deplancke, Antonio Carlos Alves Meireles Filho

In the mammalian gastrointestinal tract, distinct types of cells, including epithelial cells and macrophages, collaborate to eliminate ingested pathogens while striving to preserve the commensal microbiota. The underlying innate immune response is driven b ...

Elsevier2017

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

Didier Trono, Michaël Imbeault, Pierre-Yves Joseph Laurent Helleboid

The human genome encodes some 350 Kruppel-associated box (KRAB) domain-containing zinc-finger proteins (KZFPs), the products of a rapidly evolving gene family that has been traced back to early tetrapods(1,2). The function of most KZFPs is unknown, but a f ...

Nature Publishing Group2017

Hyperplectonemes: A Higher Order Compact and Dynamic DNA Self-Organization

Giovanni Dietler, Paolo De Los Rios, Giovanni Longo, Fabrizio Benedetti, Aleksandre Japaridze

Bacterial chromosome has a compact structure that dynamically changes its shape in response to bacterial growth rate and growth phase. Determining how chromatin remains accessible to DNA binding proteins, and transcription machinery is crucial to understan ...

American Chemical Society2017

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Johan Auwerx, Maroun Bou Sleiman

Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate dist ...

Nature Publishing Group2017

Transcription factor proteomics - Tools, applications, and challenges

Bart Deplancke, Jovan Simicevic

Transcription factors (TFs) are a family of DNA-binding proteins whose gene regulatory capabilities are of vital importance in defining the molecular state of a cell. Despite their biological significance, our understanding of TF behavior and function is s ...

Wiley-Blackwell2017

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

Christoph Merten, Luca Chiapperino, Wei Chen, Thomas Graf, Hao Sun

The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal at http://www.cell.com/cons ...

2016

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Epigenome

Mitotic chromosome binding predicts transcription factor properties in interphase

Mitotic chromosome binding predicts transcription factor properties in interphase

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Gene regulatory mechanisms underlying the intestinal innate immune response

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

Hyperplectonemes: A Higher Order Compact and Dynamic DNA Self-Organization

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Transcription factor proteomics - Tools, applications, and challenges

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

Graph Chatbot

Chat with Graph Search

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

Mitotic chromosome binding predicts transcription factor properties in interphase

Mitotic chromosome binding predicts transcription factor properties in interphase

Hyperplectonemes: A Higher Order Compact and Dynamic DNA Self-Organization

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Transcription factor proteomics - Tools, applications, and challenges

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

Gene regulatory mechanisms underlying the intestinal innate immune response