Mebane (ˈmɛbən ) is a city located mostly in Alamance County, North Carolina, United States, and partly in Orange County. The town was named for Alexander Mebane, an American Revolutionary War general and member of the U.S. Congress. It was incorporated as "Mebanesville" in 1881, and in 1883 the name was changed to "Mebane". It was incorporated as a city in 1987. The population as of the 2020 census was 17,768.
Mebane is one of the fastest-growing municipalities in North Carolina. Mebane straddles the Research Triangle and Piedmont Triad Regions of North Carolina. The bulk of the city is in Alamance County, which comprises the Burlington Metropolitan Statistical Area, itself a component of the Greensboro-Winston-Salem-High Point Combined Statistical Area. Two slivers in the eastern portion of the city are in Orange County, which is part of the Durham-Chapel Hill Metropolitan Statistical Area, itself a component of the Raleigh-Durham-Chapel Hill Combined Statistical Area.