Publications related to Karyotype

Whole-genome doubling drives oncogenic loss of chromatin segregation

Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Ruxandra-Andreea Lambuta, Juan Diaz Miyar, Giovanni Ciriello

Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies(1-8). However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotyp ...

NATURE PORTFOLIO2023

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Beat Fierz, Wei Cai, Harsh Nagpal

Centromeres are epigenetically defined via the presence of the histone H3 variant CENP-A. Contacting CENP-A nucleosomes, the constitutive centromere associated network (CCAN) and the kinetochore assemble, connecting the centromere to spindle microtubules d ...

Berlin2023

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Stephanie Jocelyne Sungalee, Ruxandra-Andreea Lambuta, Giovanni Ciriello

In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is a ...

2021

Observing protein interaction dynamics to chemically defined chromatin fibers by colocalization single-molecule fluorescence microscopy

Beat Fierz, Maxime Nicolas Mivelaz

In eukaryotic cells, the genome is packaged into chromatin and exists in different states, ranging from open euchromatic regions to highly condensed heterochromatic regions. Chromatin states are highly dynamic and are organized by an interplay of histone p ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2020

Infrared nanospectroscopic mapping of a single metaphase chromosome

Giovanni Dietler, Andrzej Kulik, Francesco Simone Ruggeri, Ewelina Wioletta Lipiec

The integrity of the chromatin structure is essential to every process occurring within eukaryotic nuclei. However, there are no reliable tools to decipher the molecular composition of metaphase chromosomes. Here, we have applied infrared nanospectroscopy ...

Oxford University Press (OUP)2019

Photophysical Heavy-Atom Effect in Iodinated Metallocorroles: Spin-Orbit Coupling and Density of States

Majed Chergui, Enrico Pomarico, Marine Eva Fedora Bouduban

Excited-state dynamics and electronic structures of Al and Ga corrole complexes were studied as a function of the number of beta-pyrrole iodine substituents. Using spectrally broad-band femtosecond-resolved fluorescence upconversion, we determined the kine ...

AMER CHEMICAL SOC2018

User-Friendly Image-Based Segmentation and Analysis of Chromosomes

Michaël Unser, Florian Maria Wurm, Lucia Baldi Unser, Ricard Delgado Gonzalo, Virginie Sophie Uhlmann

We designed two efficient and user-friendly tools for the segmentation and analysis of images containing chromosomes or, more generally, rod-shaped elements that are spread on microscopic slides. The segmentation tool allows to automatically extract the pr ...

IEEE2016

Toward an Effective Control of DNA's Submolecular Conformation on a Surface

Giovanni Dietler, Dusan Vobornik, Aleksandre Japaridze, Andrea Cerreta, Ewelina Wioletta Lipiec

DNA adopts different conformations based on its environment. We reveal conditions that either preserve the DNA's physiological B-conformation, even upon its placement in UHV, or lead to a partial B-form to A-form reorganization upon DNA's deposition on a s ...

American Chemical Society2016

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Karyotype

Whole-genome doubling drives oncogenic loss of chromatin segregation

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

Challenging endings: How telomeres prevent fragility

Observing protein interaction dynamics to chemically defined chromatin fibers by colocalization single-molecule fluorescence microscopy

Infrared nanospectroscopic mapping of a single metaphase chromosome

Revealing chromatin organization in metaphase chromosomes

Photophysical Heavy-Atom Effect in Iodinated Metallocorroles: Spin-Orbit Coupling and Density of States

User-Friendly Image-Based Segmentation and Analysis of Chromosomes

Toward an Effective Control of DNA's Submolecular Conformation on a Surface

Graph Chatbot

Chat with Graph Search

Whole-genome doubling drives oncogenic loss of chromatin segregation

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

Observing protein interaction dynamics to chemically defined chromatin fibers by colocalization single-molecule fluorescence microscopy

Challenging endings: How telomeres prevent fragility

Revealing chromatin organization in metaphase chromosomes

Photophysical Heavy-Atom Effect in Iodinated Metallocorroles: Spin-Orbit Coupling and Density of States

Infrared nanospectroscopic mapping of a single metaphase chromosome

Toward an Effective Control of DNA's Submolecular Conformation on a Surface

User-Friendly Image-Based Segmentation and Analysis of Chromosomes