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Concept
Basic leucine zipper and W2 domain-containing protein 2
Summary
Basic Leucine Zipper and W2 Domain-Containing Protein 2 is a protein that is encoded by the BZW2 gene. It is a eukaryotic translation factor found in species up to bacteria. In animals, it is localized in the cytoplasm and expressed ubiquitously throughout the body. The heart, placenta, skeletal muscle, and hippocampus show higher expression. In various cancers, upregulation tends to lead to higher severity and mortality. It has been found to interact with SARS-CoV-2.
BZW2 is known as Basic Leucine Zipper W2 Domain-Containing Protein 2, MST017, MSTP017, 5MP1, Eukaryotic Translation Factor 5, and HSPC028. It is located on chromosome 7 at p21.1 on the plus strand. The gene spans 60,389 base pairs, at coordinates 16,583,248 – 16,804,999. There are 12 exons.
There are two known isoforms of BZW2. Isoform 1 is 419 amino acids long and is the most abundant form. Isoform 2 is 225 amino acids, containing only 11 exons and a shorter N-terminus.
The coded protein is 419 amino acids long and weighs 48.3 kDa. As described in the name, the protein contains a leucine-zipper motif. Four “L......” repeats are present in the beginning, giving rise to the characteristic leucine zipper helix within the 3D structure. An eIF5C domain follows the leucine motif, which is a part of proteins that are important for strict regulation of cellular processes.
The amino acid composition of BZW2 has a higher amount of lysines and a lower amount of prolines in humans but a higher glutamic acid composition in its orthologs. The human BZW2 protein has an overall charge of -3 which can go down to -9 in orthologs. There are no significant charge clusters. There is also a KELQ repeat that has remained conserved in animals.
The secondary structure contains a majority of alpha helices. There are 19 alpha helices in all orthologs, except for two additional beta sheets which are absent in humans. The tertiary structure forms a repeated fold of alpha-helices, a structure that is conserved through bacteria.
There are three known promoters for BZW2.
Official source
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