Concept

Integrin

Related publications (83)

Tissue engineering of the bladder

Stem cell use in bladder tissue engineering is a recently addressed area of investigation that has generated excitement as a novel way to restore and regenerate lost or damaged urinary bladder tissue. The remodelling of smooth muscle plays a significant ro ...

EPFL2009

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

Etienne Meylan, Jessica Christine Vazquez

Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA-dependent activator of IRFs/Z-DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nucl ...

2009

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh, Thomas Barker, Mayumi Mochizuki Martino

The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...

Elsevier2008

Differential neuroglycan C expression during retinal degeneration in Rpe65(-/-) mice

Pascal Escher

Purpose: An increased mRNA expression of the genes coding for the extracellular matrix proteins neuroglycan C (NGC), interphotoreceptor matrix proteoglycan 2 (IMPG2), and CD44 antigen (CD44) has been observed during retinal degeneration in mice with a targ ...

2008

Engineering of extracellular matrix proteins : Integrin specific fibronectin fragment for mesenchymal stem cells differentiation and design of fibronectin-laminin fusion protein

Johann Bourget

[...] This project focuses on specific α5β1 integrin (α5β1) activation, because its crucial roles in differentiation and in adhesion have already been studied. The project is articulated in two related parts. The first and main one is dedicated to specific ...

2008

Mechanical orchestration of tissue remodeling

Pierre Jean Arnould Wipff

After organ injury, a complex sequence of events is triggered to heal the tissue and to form a scar. Myofibroblasts, specialized contractile and secretory fibroblasts, are one of the many cell types that participate in the remodeling process. Myofibroblast ...

EPFL2008

Microfluidics-Generated Immobilized Biomolecule Gradients on Hydrogels

Steffen Cosson

Extracellular matrix (ECM)-tethered morphogen gradients play an important role in tissue development and regeneration. There is currently a limited set of model systems that can mimic these gradients in an artificial ECM-like environment. Microfluidics off ...

2008

RGD-Functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells

Nikolaos Stergiopoulos, Harm-Anton Klok, Paolo Silacci, Stefano Tugulu

This report demonstrates the feasibility of surface-initiated atom transfer radical polymerization to prepare thin polymer layers ("brushes") that can be functionalized with short peptide ligands and which may be of use as coatings to promote endothelializ ...

2007

Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques

Heinrich Hofmann, Alke Fink, Benedikt Steitz

Introduction: Superparamagnetic iron oxide nanoparticles (SPIONs) have been successfully used for magnetic resonance imaging (MRI) of atherosclerotic plaques. Endocytosis into monocytes/macrophages has been proposed as the mechanism for SPION uptake, but a ...

2007

Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMs

Matthias Lütolf, Jeffrey Alan Hubbell

The elucidation of molecular cell-extracellular matrix (ECM) interactions regulating tissue dynamics necessitates straightforward model systems that can dissect the associated physiological complexity into a smaller number of distinct interactions. Here we ...

2007

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