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Genomic rearrangement of germline T-cell antigen receptor (TcR) and immunoglobulin (Ig) genes was studied by Southern blot analysis in seven patients with angioimmunoblastic lymphadenopathy (AILD). In three cases clinically suspected of transformation into ...
An IgA-producing hybridoma cell line has been grown in two hollow-fiber reactors and one fluidized-bed reactor, using a serum-contg. medium and a protein-free medium. Comparisons have been made on the basis of product quantity (total IgA) and quality (acti ...
A novel downstream process is reported for preparative scale prodn. of dimeric IgA, a protein with potential pharmaceutical applications. Time-consuming size exclusion chromatog. was replaced by ceramic hydroxyapatite chromatog. (CHT). A clear baseline sep ...
A chemically-defined protein-free medium (FMX-Turbodoma) has been improved for the production of monoclonal IgA antibodies by hybridoma cells, using a systematic method. Cell growth rate, IgA production, activity and molecular weight pattern have been used ...
This paper describes the prodn. of IgA antibodies in a range of bioreactor configurations using FCS-contg. RPMI 1640 medium. Under std. batch STR conditions, a max. viable cell and IgA concns. of 9.5*105 cell mL-1 and 47 mg l-1 were obtained. Under fed-bat ...
