Concept
IC50
Related publications (45)
Development of cyclic peptides that can be administered orally to inhibit disease targets
Christian Heinis, Manuel Leonardo Merz
Cyclic peptides can bind challenging disease targets, but their oral application is hindered by digestion and absorption issues. We developed a versatile method for the synthesis and functional screening of vast numbers of synthetic cyclic peptides and ide ...
Berlin2023Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles
Francesco Stellacci, Paulo Henrique Jacob Silva, Quy Ong Khac, Xufeng Xu, Rémi Andréa La Polla, Heyun Wang
We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...
San Diego2023Assessment of metal-based dihydrofolate reductase inhibitors on a novel mesofluidic platform
Paul Joseph Dyson, Sarah Alexandra Pais Pereira
A new miniaturized micro sequential injection coupled with the lab-on-valve (mu SIA-LOV) technique was full-blown to perform inhibitory studies on dihydrofolate reductase (DHFR). The system was used to evaluate the DHFR inhibition activity of metal-based a ...
ELSEVIER SCIENCE SA2022Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors
Pierre Vogel, Florence Pojer, George Coukos, Somi Reddy Majjigapu, Olivier Michielin
The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays an essential role in immunity, neuronal function, and aging through catalysis of the rate-limiting step in the kynurenine pathway of tryptophan metabolism. Many IDO1 inhibitors with different chemo ...
AMER CHEMICAL SOC2021Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
Huntington's disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mHTT) underpin HD p ...
NATURE PORTFOLIO2021Degradation study on molecules released from laser-based jet injector
Christophe Moser, Jan Krizek, Barbora Lavickova
Development of needle-free methods to administer injectable therapeutics has been researched for a few decades. We focused our attention on a laser-based jet injection technique where the liquid-jet actuation mechanism is based on optical cavitation. This ...
2021Impact of the skull contour definition on Leksell Gamma Knife(R)Icon (TM) radiosurgery treatment planning
Introduction The Gamma Knife(R)planning software (TMR 10, Elekta Instruments, AB, Sweden) affords two ways of defining the skull volume, the "historical" one using manual measurements (still perform in some centers) and the new one using image-based skull ...
2020Resistance to disinfection agents: Adaptation of P. aeruginosa to sub inhibitory concentrations of quaternary ammonium compounds (QACs)
Urs von Gunten, Florian Frédéric Vincent Breider, Leonardo Venturelli, Margaux Océane Voumard
Quaternary ammonium compounds (QACs) are among the most used disinfection agents in consumer products and in industrial applications. Because of their poor biodegradabil ity, after use, they will persist in technical and natural aquatic systems at sub - in ...
2019Design and validation of bioorthogonal probes for cellular disease models
Well-validated chemical probes enable testing of biological hypotheses, investigation of target tractability and translatability to the clinical phase. Consequently, these important tool compounds play a key role in the drug discovery process. Moreover, th ...
EPFL2019Discovery of novel competitive dihydropteridine reductase inhibitors via high throughput screening and their effect on metabolic pterin balance of fibroblast.
The development of tool compounds for the study of the tetrahydrobiopterin (BH4) metabolic network perturbation is of interest especially in the case of oxidative and nitrosative stress genesis. A semisynthetic FRET sensor was engineered in order to study ...
EPFL2018