Concept
Cyclin-dependent kinase 5
Related publications (22)
Dopamine Transporter, PhosphoSerine129 alpha-Synuclein and alpha-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice
Salvatore Novello, Chiara Domenicale
The G2019S mutation in leucine rich-repeat kinase 2 (LRRK2) is a major cause of familial Parkinson's disease. We previously reported that G2019S knock-in mice manifest dopamine transporter dysfunction and phosphoSerine129 alpha-synuclein (pSer129 alpha-syn ...
MDPI2022Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity
Henry Markram, Srikanth Ramaswamy, Cristina Colangelo
Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models and simulations enable predictions on the potential role of ACh in reconfiguring netwo ...
2018Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage
Gérald Joseph Paul Lossaint, Katarina Bacevic
Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1. Yet Cdk2 also has non-redundant functions that can be revealed in certain genetic ...
Springer Nature2017Estimation of PKC delta autophosphorylation in U87 MG glioma cells: combination of experimental, conceptual and numerical approaches
Jaroslava Joniová, Veronika Huntosova
Golgi apparatus (GA) is a center for lipid metabolism and the final target of ceramide pathway, which may result in apoptosis. In this work localization of highly hydrophobic hypericin is followed by time-resolved imaging of NBDC6 (fluorescent ceramide) in ...
Wiley-V C H Verlag Gmbh2017CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanism ...
Cell Press2015