Concept

Iron deficiency

Related publications (72)

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

BACKGROUND: Existing animal models of anemia inadequately reflect the hematocrit usually present in chronic renal failure (CRF) patients and do not permit long-term treatment studies. The transgenic mouse strain 134.3LC (Epo-TAg(H)) displays a severe chron ...

2002

Finite-length analysis of various low-density parity-check ensembles for the binary erasure channel

Rüdiger Urbanke, Mohammad Amin Shokrollahi

We investigate the average erasure probability of the belief propagation algorithm over the binary erasure channel (BEC) for various finite-length low- density parity-check (LDPC) ensembles. In particular, we give tight upper bounds on the "error floor", i ...

2002

Mechanisms of differential transferrin receptor expression in normal hematopoiesis

Lukas Kühn

We have investigated the expression of transferrin receptor (TfR) iron regulatory protein-1 (IRP-1) and iron regulatory protein-2 (IRP-2) in liquid suspension culture of purified hematopoietic progenitor cells (HPCs) induced by a growth factor stimulus to ...

2000

Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption

Lukas Kühn

Duodenal enterocytes adjust intestinal iron absorption to the body's state of iron repletion. Here we tested how iron supply from the blood modulates the RNA-binding activity of iron regulatory proteins (IRP-1 and IRP-2) in immature duodenal rat enterocyte ...

1999

Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

Lukas Kühn

The puzzling linkage between genetic hemochromatosis and histocompatibility loci became even more so when the gene involved, HFE, was identified. Indeed, within the well defined, mainly peptide-binding, MHC class I family of molecules, HFE seems to perform ...

1999

Geochemical changes during biodegradation of petroleum hydrocarbons: Field investigations and biogeochemical modelling

David Andrew Barry

Sediment analysis using wet extraction techniques and model simulations were carried out to investigate the role of ferric iron during biodegradation of dissolved petroleum hydrocarbon compounds at a field site in Perth, Western Australia. Sediment cores w ...

1999

Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA

Lukas Kühn

Iron regulatory proteins (IRPs) control the synthesis of several proteins in iron metabolism by binding to iron-responsive elements (IREs), a hairpin structure in the untranslated region (UTR) of corresponding mRNAs. Binding of IRPs to IREs in the 5' UTR i ...

1999

Identification of RNA-binding surfaces in iron regulatory protein-1

Lukas Kühn

Post-transcriptional regulation of mRNA translation and stability in iron metabolism involves the interaction between the trans-acting cytoplasmic iron regulatory proteins (IRP-1 and IRP-2) and cis-acting iron-responsive elements (IREs) in mRNA 5'- or 3'-u ...

1999

Transferrin receptor expression is controlled differently by transferrin-bound and non-transferrin iron in human cells

Lukas Kühn

We studied the effects of iron supplied as transferrin-bound iron and iron supplied as non-transferrin iron on transferrin receptor expression by human cell lines. Defined conditions of iron supply were represented by (i) 5 microg/ml of iron-saturated tran ...

1998

Translational regulation of mRNAs with distinct IRE sequences by iron regulatory proteins 1 and 2

Lukas Kühn

Iron regulatory proteins 1 and 2 (IRP-1, IRP-2) interact with iron-responsive elements (IREs) present in the 5'- or 3'-untranslated regions (UTR) of several mRNAs coding for proteins in iron metabolism. Whereas binding of IRP-1 and -2 to an IRE in the 5'-U ...

1998

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