Publications related to Metabolic engineering

TOWARD THE IDENTIFICATION OF NEW CANCER THERAPY TARGETS USING METABOLIC MODELING IN A HUMAN GENOME SCALE

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Maria Masid Barcon

Cancer is a leading cause of death in the world, and the mechanisms that underlie this disease are still not completely understood. In the last decades, altered tumor metabolism has been recognized as one of the hallmarks of cancer. Modeling the different ...

2017

Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences

Vassily Hatzimanikatis, Homa Mohammadi Peyhani, Noushin Hadadi

A key challenge in metabolic engineering is to design novel or to improve existing biosynthetic pathways that lead to the cellular production of a given industrial or pharmaceutical compound. In many cases, the required enzymatic reactions for the biosynth ...

2017

redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Daniel Federico Hernandez Gardiol

Genome-scale metabolic reconstructions have proven to be valuable resources in enhancing our understanding of metabolic networks as they encapsulate all known metabolic capabilities of the organisms from genes to proteins to their functions. However the co ...

2017

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Vassily Hatzimanikatis, Ljubisa Miskovic, Georgios Fengos

Systematic analysis for the redirection of carbon flux in metabolite-producing microorganisms requires the comprehensive understanding of their complex metabolic processes. The use of large-scale dynamic models of metabolism plays key role in the understan ...

2016

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Vassily Hatzimanikatis, Ljubisa Miskovic, Georgios Fengos

2016

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using Large-scale kinetic models

Vassily Hatzimanikatis, Ljubisa Miskovic, Anirikh Chakrabarti, Stefano Andreozzi

Rational metabolic engineering methods are increasingly employed in designing the commercially viable processes for the production of chemicals relevant to pharmaceutical, biotechnology, and food and beverage industries. With the growing availability of om ...

2016

Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh, Stefano Andreozzi

Elsevier2016

ATLAS of Biochemistry: A Repository of All Possible Biochemical Reactions for Synthetic Biology and Metabolic Engineering Studies

Vassily Hatzimanikatis, Jasmin Maria Hafner, Adrian Shajkofci, Noushin Hadadi, Aikaterini Zisaki

Because the complexity of metabolism cannot be intuitively understood or analyzed, computational methods are indispensable for studying biochemistry and deepening our understanding of cellular metabolism to promote new discoveries. We used the computationa ...

Amer Chemical Soc2016

Discovery and Evaluation of Novel Pathways for Production of the Second Generation of Biofuels

Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Noushin Hadadi, Milenko Tokic

In an effort of overcoming the limited availability of fossil energy resources the focus of the research and development in the area of biofuels has moved towards developing the second generation of fuels that should be produced via microbial fermentation. ...

2016

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Metabolic engineering

TOWARD THE IDENTIFICATION OF NEW CANCER THERAPY TARGETS USING METABOLIC MODELING IN A HUMAN GENOME SCALE

Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks

Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences

redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using Large-scale kinetic models

Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

ATLAS of Biochemistry: A Repository of All Possible Biochemical Reactions for Synthetic Biology and Metabolic Engineering Studies

Discovery and Evaluation of Novel Pathways for Production of the Second Generation of Biofuels

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Chat with Graph Search

Exploring enhancement of 1,4-butanediol production in recombinant E. coli using Large-scale kinetic models

TOWARD THE IDENTIFICATION OF NEW CANCER THERAPY TARGETS USING METABOLIC MODELING IN A HUMAN GENOME SCALE

Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks

Evaluating the similarity of biochemical reactions and its uses for mapping novel reactions to protein sequences

redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Analysis and Design of Metabolic Engineering and Synthetic Biology Strategies using Large Scale Dynamic Models of Metabolism

Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

ATLAS of Biochemistry: A Repository of All Possible Biochemical Reactions for Synthetic Biology and Metabolic Engineering Studies

Discovery and Evaluation of Novel Pathways for Production of the Second Generation of Biofuels