Concept

Metabolic engineering

Related publications (95)

Metabolic engineering under uncertainty. I: Framework development

Std. bioprocess conditions have been widely applied for the microbial conversion of raw material to essential industrial products. Successful metabolic engineering (ME) strategies require a comprehensive framework to manage the complexity embedded in cellu ...

2006

Exploring the diversity of complex metabolic networks

Vassily Hatzimanikatis

Motivation: Metab., the network of chem. reactions that make life possible, is one of the most complex processes in nature. We describe here the development of a computational approach for the identification of every possible biochem. reaction from a given ...

2005

Exploring the diversity of metabolism

Vassily Hatzimanikatis

We describe the development of a computational approach for the identification of every possible biochem. reaction from a given set of enzyme reaction rules that allows the de novo synthesis of metabolic pathways composed of these reactions, and the evalua ...

2005

Run-to-run Optimization of Filamentous Fungal Fermentation

Dominique Bonvin, Levente Bodizs

Improving the productivity of fed-batch filamentous fungal fermentations can be formulated as a dynamic optimization problem. However, numerical optimization based on a nominal process model is typically insufficient when uncertainty in the form of model m ...

2005

Metabolic control analysis under uncertainty: Framework development and case studies

Vassily Hatzimanikatis

Information about the enzyme kinetics in a metabolic network will enable understanding of the function of the network and quant. prediction of the network responses to genetic and environmental perturbations. Despite recent advances in exptl. techniques, s ...

2004

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology

Johan Auwerx

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a prototypical member of the nuclear receptor superfamily and integrates the control of energy, lipid, and glucose homeostasis. PPARgamma can bind a variety of small lipophilic compounds d ...

2004

Quantification and characterization of uncertainty in metabolic engineering

Vassily Hatzimanikatis

One of the central problems in metabolic engineering deals with the identification of the "rate limiting steps", i.e. enzymes whose activities one should manipulate towards the achievement of a desirable performance. However, uncertainty about the kinetic ...

2003

Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes

Vassily Hatzimanikatis

A review. The classical method of metabolic engineering, identifying a rate-detg. step in a pathway and alleviating the bottleneck by enzyme overexpression, has motivated much research but has enjoyed only limited practical success. Intervention of other l ...

2002

A memorial review of Jay Bailey's contribution in prokaryotic metabolic engineering

Vassily Hatzimanikatis

A review, with refs. When mentioning prokaryotic metabolic engineering, most people will immediately think of Jay Bailey. Jay's contribution to this fast-growing field is evident and familiar to many. Therefore, instead of a detailed tech. review, we attem ...

2002

Heat flux as an on-line indicator of metabolic activity in pilot scale bioreactor during the production of Bacillus thuringiensis var. galleriae-based biopesticides

Urs von Stockar, Ian William Marison

The effective biotechnol. process development depends on the system for monitoring the activity of the culture during cultivation. The feasibility of monitoring the metabolic flux during the cultivation of Bacillus thuringiensis var. galleriae (Btg) in pil ...

2002

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